摘要: Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC population that express typical pDC markers including CD123 and BDCA2 but produce much less IFN-I comparing with pDCs. In addition, CD56(+) DCs cluster together with mDCs but not pDCs by genome-wide transcriptional profiling. Accordingly, CD56(+) DCs functionally resemble mDCs by producing IL-12 upon TLR4 stimulation and priming naive T cells without prior activation. These data suggest that the CD56(+) DCs represent a novel mDC subset mixed with some pDC features. A CD4(+)CD56(+) hematological malignancy was classified as blastic plasmacytoid dendritic cell neoplasm (BPDCN) due to its expression of characteristic molecules of pDCs. However, we demonstrated that BPDCN is closer to CD56(+) DCs than pDCs by global gene-expression profiling. Thus, we propose that the CD4(+)CD56(+) neoplasm may be a tumor counterpart of CD56(+) mDCs but not pDCs.
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期刊:
PROTEIN & CELL
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分类:
生物学
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生物物理学
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细胞生物学
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引用:
ChinaXiv:201605.01258
(或此版本
ChinaXiv:201605.01258V1)
doi:10.12074/201605.01258
CSTR:32003.36.ChinaXiv.201605.01258.V1
- 推荐引用方式:
Yu, Haisheng,Yin, Xiangyun,Zhang, Liguo,Zhang, Peng,Cui, Ya,Jiang, Taijiao,Yu, Haisheng,Zhang, Peng,Yin, Xiangyun,Yin, Zhao,Shi, Quanxing,Wang, Shouli,Liu, Guanyuan,Piccaluga, Pier Paolo.(2016).Human BDCA2(+)CD123(+)CD56(+) dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset.PROTEIN & CELL.[ChinaXiv:201605.01258]
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