摘要: Mucosal immunity protects a host from intestinal inflammation and infection and is profoundly influenced by symbiotic bacteria. Here we report that in mice symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2, a cytosolic bacterial sensor, and the multifunctional protein kinase LRRK2, both encoded by inflammatory bowel disease (IBD)-associated genes. Commensals recruited Nod2 onto lysozyme-containing dense core vesicles (DCVs), which was required for DCV localization of LRRK2 and a small GTPase, Rab2a. Deficiency of Nod2, LRRK2 or Rab2a or depletion of commensals resulted in lysosomal degradation of lysozyme. Thus, commensal bacteria and host factors orchestrate the lysozyme-sorting process to protect the host from enteric infection, implicating Paneth cell dysfunction in IBD pathogenesis.
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期刊:
NATURE IMMUNOLOGY
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分类:
生物学
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生物物理学
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免疫学
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引用:
ChinaXiv:201605.01367
(或此版本
ChinaXiv:201605.01367V1)
doi:10.12074/201605.01367
CSTR:32003.36.ChinaXiv.201605.01367.V1
- 推荐引用方式:
Zhang, Qin,Pan, Ying,Yan, Ruiqing,Wang, Haifang,Zhang, Xinwen,Liu, Zhihua,Zeng, Benhua,Li, Wenxia,Wei, Hong,Liu, Zhihua.(2016).Commensal bacteria direct selective cargo sorting to promote symbiosis.NATURE IMMUNOLOGY.[ChinaXiv:201605.01367]
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