Furin, a potential therapeutic target for COVID-19

Submit Time: 2020-02-23

Author: Hua Li 1,2 ; Canrong Wu 1 ; Yueying Yang 2 ; Yang Liu 2 ; Peng Zhang 2 ; Yali Wang 2 ; Qiqi Wang 2 ; Yang Xu 2 ; Mingxue Li 2 ; Mengzhu Zheng 1 ; Lixia Chen 2 ;

Institute: 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2.Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;

Abstracts

A novel coronavirus (SARS-CoV-2) infectious disease has broken out in Wuhan, Hubei Province since December 2019, and spread rapidly from Wuhan to other areas, which has been listed as an international concerning public health emergency. We compared the Spike proteins from four sources, SARS-CoV-2, SARS-CoV, MERS-CoV and Bat-CoVRaTG13, and found that the SARS-CoV-2 virus sequence had redundant PRRA sequences. Through a series of analyses, we propose the reason why SARS-CoV-2is more infectious than other coronaviruses. And through structure based virtual ligand screening, we foundpotentialfurin inhibitors, which might be used in the treatment of new coronary pneumonia.

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From: 李华

Subject: Medicine, Pharmacy >> Pharmacology

DOI：10.12074/202002.00062

Keywords: SARS-CoV-2; Spike proteins; Furin; Inhibitors; Virtual screening;

Cite as: chinaXiv:202002.00062 (or this versionchinaXiv:202002.00062V1)

Recommended references： Hua Li,Canrong Wu,Yueying Yang,Yang Liu,Peng Zhang,Yali Wang,Qiqi Wang,Yang Xu,Mingxue Li,Mengzhu Zheng,Lixia Chen.(2020).Furin, a potential therapeutic target for COVID-19.[ChinaXiv:202002.00062] (Click&Copy)