Cryo-EM structure of SARS-CoV spike glycoprotein in post-fusion state

Submit Time: 2020-03-06

Author: Fan, Xiaoyi 1,2 ; Cao, Duanfang 1 ; Kong, Lingfei 1 ; Zhang, Xinzheng 1,2,3 ;

Institute: 1.National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China; 2.University of Chinese Academy of Sciences, Beijing 100049, P.R. China; 3.Center for Biological Imaging, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China;

Abstracts

冠状病毒SARS-CoV，MERS-CoV和新发现的2019-nCoV所引发的传染性疾病严重威胁着人类的生命健康安全。位于冠状病毒表面的spike（S）糖蛋白在病毒传播及感染过程中负责结合宿主细胞受体，融合细胞中的膜结构等关键步骤，是病毒重要的药物靶点。其中在冠状病毒中高度保守的S2亚基作为融膜机器，介导了病毒与宿主之间的膜融合过程。我们运用冷冻电镜单颗粒三维重构技术解析了SARS-CoV S糖蛋白的融膜后构象的结构，展示了S2亚基在融膜过程中的结构特点和构象变化。结合保守性比对和糖基化修饰指认，这项工作分析了位于S2亚基的潜在药物靶点，有益于相关疫苗和药物的开发和设计。

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From: 曹端方

Subject: Biology >> Virology

DOI：10.12074/202003.00046

Keywords: SARS-CoV; spike; 融膜后构象; 融膜机制; 糖蛋白;

Cite as: chinaXiv:202003.00046 (or this versionchinaXiv:202003.00046V1)

Recommended references： Fan, Xiaoyi,Cao, Duanfang,Kong, Lingfei,Zhang, Xinzheng.(2020).Cryo-EM structure of SARS-CoV spike glycoprotein in post-fusion state.[ChinaXiv:202003.00046] (Click&Copy)

Version History
[V1]	2020-03-06 14:05:48	chinaXiv:202003.00046V1	Download

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Cryo-EM structure of SARS-CoV spike glycoprotein in post-fusion state

Abstracts

1. “One-to-three” droplet generation-based digital microfluidics for parallel immunoassay.docx 2021-04-07

2. Taxonomic revision of the holotype of Proboselaphus watasei Matsumoto, 1915 (Bovidae, Artiodactyla) from Chuanyu area, China 2021-04-02

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4. An Upper Miocene “Hipparion fauna” locality sandwiched by basalts in Hanjiaying, Nei Mongol 2021-04-02

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6. Taxonomic identity of Primulina swinglei (Gesneriaceae) 2020-10-20

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10. Late Miocene micromammalian assemblage of Tuchengzi and its biochronological position in Neogene faunal sequence in central Nei Mongol, China 2020-09-15

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