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1990—2019 年中国痛风疾病负担趋势及未来十年预测研究

Trend Analysis of Gout Burden in China from 1990 to 2019 and Prediction for the Next Ten Years

摘要: 背景 痛风是最常见的炎症性关节炎,对人们的健康造成很大的危害,但目前针对我国痛风疾病负担趋势分析与预测的相关研究有限。目的 分析 19902019 年中国痛风疾病负担的变化趋势,并预测未来 10 年痛风的标化 DALYs 率、标化发病率和标化患病率。方法 提取全球疾病负担研究(GBD)2019 有关中国痛风伤残调整寿命年(DALYs)、发病情况和患病情况等疾病负担指标,采用 Joinpoint 回归模型计算标化 DALYs 率、发病率和患病率的年度变化百分比(APC)和平均年度变化百分比(AAPC),采用自回归移动平均模型(ARIMA 模型)对 20202029 年的标化 DALYs 率、标化发病率和标化患病率进行预测。结果 19902019 年,中国痛风 DALYs 从 187 436 人年增至 510 485 人年,增长了 172.35%,发病人数从 1 181 969 人增至 3 041 329 人,增长了 157.31%,患病人数从 5864 143 人增至 16 161 325 人,增长了 175.60%(对应的标化率分别增长了 28.45%、25.92% 和 28.63%)。Joinpoint 回归结果显示,19902019 年,标化 DALYs 率、发病率、患病率整体呈上升趋势(AAPC 分别为 0.9%、0.8%、0.9%,P

Abstract: Background Gout is the most common inflammatory arthritis,which causes great harm to people's health,however,there are limited studies on the trend analysis and prediction of gout burden in China. Objective To analyze the changing trend of gout in China from 1990 to 2019,and predict the standardized DALYs rate,incidence rate and prevalence rate of gout in the next 10 years. Methods The indicators of disability-adjusted life years(DALYs),incidence,and prevalence of gout in China were extracted from the Global Burden of Disease Study(GBD2019),the annual percentage change(APC) and annual average percentage change(AAPC) of the age-standardized DALYs rate,age-standardized incidence rate and age-standardized prevalence rate were calculated using the Joinpoint regression model,autoregressive integrated moving average model(ARIMA model) was used to predict the the age-standardized DALYs rate,age-standardized incidence rate and age-standardized prevalence rate in 2020-2029. Results In 1990-2019,the DALYs of gout in China increased from 187 436 to 510 485 person-years,with an increase of 172.35%,the number of cases increased from 1 181 969 to 3 0411 329,with an increase of 157.31%,the number of patients increased from 5 864 143 to 16 161 325,with an increase of 175.60%(the corresponding standardized rates increased by 28.45%,25.92% and 28.63%,respectively). Joinpoint regression results showed an overall increasing trend in the age-standardized DALYs rate,age-standardized incidence rate and age-standardized prevalence rate(AAPC was 0.9%,0.8%,0.9%,respectively,P

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[V1] 2023-09-13 16:03:24 ChinaXiv:202309.00128V1 下载全文
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