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1. chinaXiv:201612.00373 [pdf]

Prospect of a very long baseline neutrino oscillation experiment: HIPA to Beijing

H2B-1,VSG; Chen,H; Ding,L; He,J; Kuang,H; Lu,Y; Ma,Y; Shan,L; Shen,C; Wang,Y; Yang,C; Zhang,X; Zhu,Q; Qing,C; Xiong,Z; Yang,JM; Zhang,Z; Chen,J; Ye,Y; Lee,S

We discuss the prospects of a very long baseline neutrino oscillation experiment from HIPA to Beijing. The current understanding of neutrino oscillations, both theoretically and experimentally, are summarized. The figure of merits for interested physics m

submitted time 2016-12-28 Hits1620Downloads827 Comment 0

2. chinaXiv:201605.00748 [pdf]

c-Abl-p38 alpha signaling plays an important role in MPTP-induced neuronal death

Wu, R.; Chen, H.; Ma, J.; He, Q.; Yuan, Z.; Wu, R.; Ma, J.; He, Q.; Yuan, Z.; Chen, H.; Yuan, Z.; Huang, Q.; Li, M.; Huang, Q.; Li, M.; Liu, Q.;
Subjects: Biology >> Biophysics >> Biochemistry & Molecular Biology

Oxidative stress is a major cause of sporadic Parkinson's disease (PD). Here, we demonstrated that c-Abl plays an important role in oxidative stress-induced neuronal cell death. C-Abl, a nonreceptor tyrosine kinase, was activated in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP)-induced acute PD model. Conditional knockout of c-Abl in neurons or treatment of mice with STI571, a c-Abl family kinase inhibitor, reduced the loss of dopaminergic neurons and ameliorated the locomotive defects induced by short-term MPTP treatment. By combining the SILAC (stable isotope labeling with amino acids in cell culture) technique with other biochemical methods, we identified p38 alpha as a major substrate of c-Abl both in vitro and in vivo and c-Abl-mediated phosphorylation is critical for the dimerization of p38 alpha. Furthermore, p38 alpha inhibition mitigated the MPTP-induced loss of dopaminergic neurons. Taken together, these data suggested that c-Abl-p38 alpha signaling may represent a therapeutic target for PD.

submitted time 2016-05-05 Hits1351Downloads733 Comment 0

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