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1. chinaXiv:202002.00018 [pdf]

2019-novel coronavirus (2019-nCoV) infections trigger an exaggerated cytokine response aggravating lung injury

Yingxia Liu; Cong Zhang; Fengming Huang; Yang Yang; Fuxiang Wang; Jing Yuan; Zheng Zhang; Yuhao Qin; Xiaoyun Li; Dandan Zhao; Shunwang Li; Shuguang Tan; Zhaoqin Wang; Jinxiu Li; Chenguang Shen; Jianming Li; Ling Peng; Weibo Wu; Mengli Cao; Li Xing
Subjects: Biology >> Biochemistry

最近,在中国武汉爆发了肺炎病例,由一种名为2019-CoV的新型冠状病毒引起。我们之前的研究中,根据中国深圳的12例2019-nCoV感染患者的临床特征,所有病例均患有肺炎,一半病例发展为急性呼吸窘迫综合征(ARDS)。本文中,我们针对这12例患者的血浆因子表达谱进行了研究。我们测试了2019-nCoV感染患者血浆中的48个因子的表达,其中38个因子与健康个体相比显着升高;2019-nCoV感染的重症患者血浆中的高细胞因子血症水平显著低于A型流感病毒H7N9感染患者,而略高于细菌感染患者。在这38个细胞因子中,有17个与2019-CoV病毒载量相关,其中的15个(M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1受体拮抗剂,G-CSF,IL-12 (p40),IFN-γ,IL-1α,IL-2,HGF和PDGF-BB)与肺损伤Murray评分高度相关,可用来预测2019-nCoV感染患者的疾病严重程度。我们的研究结果表明,这15种高细胞因子可能是衡量2019-nCoV感染患者疾病严重程度的潜在生物标志物,影响这些信号传递介质的因子可能是针对新型2019-nCoV大流行的潜在药物。

submitted time 2020-02-12 Hits22059Downloads3873 Comment 0

2. chinaXiv:202002.00014 [pdf]

Clinical and Biochemical Indexes from 2019-nCoV infected patients linked to viral loads and lung injury

Yingxia Liu; Yang Yang; Cong Zhang; Fengming Huang; Fuxiang Wang; Jing Yuan; Zhaoqin Wang; Jingxiu Li; Jianming Li; Cheng Feng; Zheng Zhang; Lifei Wang; Ling Peng; Li Chen; Yuhao Qin; Dandan Zhao; Shuguang Tan; Lu Yin; Jun Xu; Congzhao Zhou
Subjects: Biology >> Biochemistry

新型冠状病毒(2019-nCoV)自2019年12月在湖北省武汉市爆发,并迅速传播到中国多地及其他国家。在本研究中,我们报告了来自中国深圳早期的2019-nCoV感染患者的流行病学、临床指标、生化指标和影像学特征,以及可用于预测疾病严重程度的潜在生物标记物。所有12例2019-nCoV感染的肺炎患者均发展为肺炎,其中一半患者进一步发展为急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)。最常见的实验室检测生化指标异常是低白蛋白(albumine,ALB)血症、淋巴细胞(lymphocytes,LYM)计数减少,淋巴细胞百分比和中性粒细胞(neutrophils,NEU)百分比降低,C反应蛋白(C-reactive protein,CRP)和乳酸脱氢酶(lactate dehydrogenase,LDH)水平升高,以及CD8细胞计数降低。从患者呼吸道特别是下呼吸道检测到的2019-nCoV病毒滴度与肺部疾病的严重程度正相关。 ALB、LYM、LYM(%)、LDH、NEU(%)和CRP的水平与急性肺损伤程度高度相关。年龄、病毒滴度、肺损伤评分和血液生化指标:ALB、CRP、LDH、LYM(%)、LYM和NEU(%)可能是疾病严重程度的预测指标。此外, 2019-nCoV感染患者的血浆血管紧张素II水平显着升高,并且与病毒滴度和肺损伤程度线性相关。我们的研究结果提供了多种潜在的可用于诊断的生物标志物, 并提出了血管紧张素 II受体阻滞剂(angiotensin II receptor blocker,ARB)药物或可作为治疗2019-nCoV感染的潜在药物进行深入研究。

submitted time 2020-02-08 Hits8847Downloads1447 Comment 0

3. chinaXiv:201803.01550 [pdf]

Enhanced thermoelectric performance of CuGaTe2 by Gd-doping and Te incorporation

Jian Zhang; Xiaoying Qin; Di Li; Chunjun Song; Xiaoguang Zhu; Yongfei Liu; Hongxing Xin; Li Chen; Tianhua Zou
Subjects: Physics >> Interdisciplinary Physics and Related Areas of Science and Technology

Gd-doped compounds CuGa1-xGdxTe2 (0?x?0.02) incorporated with tellurium nanoparticles are synthesized by fusion method. Their thermoelectric properties are investigated in the temperature range of 300-800K. The results indicate that the synergistic effect of Gd-doping and Te incorporation remarkably enhances the thermoelectric performance of CuGaTe2. Specially, the thermal conductivity ? of the specimen CuGa0.98Gd0.02Te2/0.7vol.%Te reduces to 0.45 Wm-1K-1 at 684K, which is ~74% smaller than that of pure CuGaTe2 (?=1.76 W?m-1?K-1 at 684K) due to the incorporation of nanostructure Te. The thermoelectric figure of merit value (ZT) reaches 0.75 at 737K for the specimen CuGa0.99Gd0.01Te2/0.7vol.%Te, which is ~115% larger than that of pure CuGaTe2.

submitted time 2018-03-30 Hits2283Downloads1117 Comment 0

4. chinaXiv:201711.02257 [pdf]

Insight-HXMT observations of the first binary neutron star merger GW170817

TiPei Li; ShaoLin Xiong; ShuangNan Zhang; FangJun Lu; LiMing Song; XueLei Cao; Zhi Chang; Gang Chen; Li Chen; TianXiang Chen; Yong Chen; YiBao Chen; YuPeng Chen; Wei Cui; WeiWei Cui; JingKang Deng; YongWei Dong; YuanYuan Du; MinXue Fu; GuanHua Gao
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Finding the electromagnetic (EM) counterpart of binary compact star merger, especially the binary neutron star (BNS) merger, is critically important for gravitational wave (GW) astronomy, osmology and fundamental physics. On Aug. 17, 2017, Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope (HE) onboard Insight-HXMT (Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart (SSS17a/AT2017gfo) with very large collection area (~1000 cm2) and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity (ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy (0.2-5 MeV) radiation from GW170817, its observation helped to confirm the nexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints (~10-7 to 10-6 erg/cm2/s) for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.

submitted time 2017-11-10 Hits1516Downloads821 Comment 0

5. chinaXiv:201711.00140 [pdf]

Crystal Structure and ESIPT Phenomena of Anionic 2H-Phenanthro[9,10-c]pyrazol-11-ols

LI Chen-Chen; HE Yun; WEI Tao; WANG Tao; ZHANG Zun-Ting
Subjects: Chemistry >> Physical Chemistry

Using 4?-methoxy-5-hydroxyisoflavone and 4?,5-dihydroxy-7-methoxyisoflavone as leding compounds, 6-methoxy-2H-phenanthro[9,10-c]pyrazol-11-ol (1a) and 9-methoxy-2H-phenanthro [9,10-c]pyrazol-6,11-diol (1b) were synthesized by two dehydration processes in the EtOH solution. They were characterized by IR, 1H NMR and 13C NMR. The black prism crystal of 1a was grown by the slow solvent evaporation technique from 40:1 (v/v) CHCl3/MeOH, and it was determined by single-crystal X-ray diffraction. In the crystal structure, 1a was stabilized by intramolecular (O–H···N) and intermolecular (N–H···O, O–H···O, π···π, C–H···π) interactions. In addition, the fluorescence properties of 1a and 1b in the base and neutral media revealed that they possessed excited state intramolecular proton transfer phenomena (ESIPT).

submitted time 2017-11-05 From cooperative journals:《结构化学》 Hits1585Downloads798 Comment 0

6. chinaXiv:201711.00144 [pdf]

Europium Coordination Compound with Highly Improved Luminescent Quantum Yield

LI Xin; LI Chen-Yuan; ZHENG Wei-Wei; YANG Dan; XIONG Ke-Cai; GAI Yan-Li
Subjects: Chemistry >> Physical Chemistry

The luminescent properties of two Eu3+ compounds based on quinoline-2-carboxylic acid (Hqc), [Na2Eu2(qc)6(CH3COO)2(H2O)4].2DMF (1) and [Eu2(qc)6(H2O)6].3H2O (2), as well as their syntheses and structures are reported. Both compounds are formed by slow evaporation at room temperature and exhibit zero dimensional dinuclear structures. It is worth mentioning that a 4.5-fold enhancement in luminescent quantum yield is achieved by reducing the nonradiative deactivation, through which the quantum yield increases remarkably to 67.62% for 1 compared with 12.18% for 2.

submitted time 2017-11-05 From cooperative journals:《结构化学》 Hits1159Downloads659 Comment 0

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