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1. chinaXiv:202002.00061 [pdf]

2019新型冠状病毒核衣壳蛋白N能发挥病毒编码的RNAi抑制子功能

Mu, Jingfang; Xu, Jiuyue; Shu, Ting; Wu, Di; Huang, Muhan; Ren, Yujie; Li, Xufang; Geng, Qing; Xu, Yi; Qiu, Yang; Zhou, Xi
Subjects: Biology >> Virology

新型冠状病毒肺炎目前仍在武汉和中国其他地区持续。在目前的形势下,进一步了解新型冠状病毒(SARS-CoV-2)的病毒学和病毒与宿主的相互作用,对控制感染、开发有效的治疗方法具有重要意义。RNA干扰(RNA interference,RNAi)是一种进化上保守的真核生物抗病毒免疫机制,目前已发现许多病毒编码自身的RNA干扰抑制因子作为对抗措施。在这项研究中,我们发现SARS-CoV-2编码的核衣壳蛋白(N)有效地抑制了shRNAs或siRNAs触发的RNAi。此外,与许多由其他病毒编码的VSR类似,SARS-CoV-2的VSR在体外与人类细胞中与dsRNA相互作用,显示出双链RNA(dsRNA)结合活性。综上所述,我们的研究结果表明,SARS-CoV-2的N蛋白在人类细胞中表现出VSR活性,这可能是新型冠状病毒的一个关键免疫逃避因子。

submitted time 2020-02-22 Hits9836Downloads1790 Comment 0

2. chinaXiv:201711.00148 [pdf]

Synthesis, Crystal Structure and Biological Activity of 1-(4-(4-Ethoxybenzyl)piperazin-1-yl)-2- (2-methylphenoxy)ethanone

LI Xiao-Feng; CHEN Xiao-Hong; ZHONG Yan; XU Yi; LI Ping; WU Bin
Subjects: Chemistry >> Physical Chemistry

One novel phenoxyacetamide derivative (C22H28N2O3, Mr = 368.47) has been synthesized and determined by means of NMR spectroscopy, high resolution mass spectra and single-crystal X-ray diffraction. The single crystal belongs to the monoclinic system, space group Cc with a = 14.910(3), b = 14.592(3), c = 38.683(8) ?, β = 100.37(3)°, V = 8279(3) ?3, Z = 16, Dc = 1.183 g/cm3, F(000) = 3168, μ = 0.079 mm-1, MoKα radiation (λ = 0.71073 ?), the final R = 0.0508 and wR = 0.0666 for 4120 observed reflections with I > 2σ(I). There are four independent molecules in an asymmetric unit cell. The four symmetry-independent molecules have a variety of different conformations indicating considerable conformational freedom. The bioassay results indicated that the title compound displayed effective activities against glutamine-induced neurotoxicity in PC12 cells and significantly prolonged the survival time of mice subjected to acute cerebral ischemia.

submitted time 2017-11-05 From cooperative journals:《结构化学》 Hits1144Downloads681 Comment 0

3. chinaXiv:201609.01004 [pdf]

The evolution of the magnetic inclination angle as an explanation of the long term red timing-noise of pulsars

Shu-Xu Yi; Shuang-Nan Zhang
Subjects: Physics >> Nuclear Physics

We study the possibility that the long term red timing-noise in pulsars originates from the evolution of the magnetic inclination angle?χ. The braking torque under consideration is a combination of the dipole radiation and the current loss. We find that the evolution of?χ?can give rise to extra cubic and fourth-order polynomial terms in the timing residuals. These two terms are determined by the efficiency of the dipole radiation, the relative electric-current density in the pulsar tube and?χ. The following observation facts can be explained with this model: a) young pulsars have positive?ν¨; b) old pulsars can have both positive and negative?ν¨; c) the absolute values of?ν¨?are proportional to??ν˙; d) the absolute values of the braking indices are proportional to the characteristic ages of pulsars. If the evolution of?χ?is purely due to rotation kinematics, then it can not explain the pulsars with braking index less than 3, and thus the intrinsic change of the magnetic field is needed in this case. Comparing the model with observations, we conclude that the drift direction of?χ?might oscillate many times during the lifetime of a pulsar. The evolution of?χ?is not sufficient to explain the rotation behavior of the Crab pulsar, because the observed?χand?χ˙?are inconsistent with the values indicated from the timing residuals using this model.

submitted time 2016-09-14 Hits1065Downloads590 Comment 0

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