分类： 医学、药学 >> 基础医学 提交时间： 2022-03-02
摘要： Objective To explore the effect of high intensity interval training (HIIT) on blood glucose control in experimental animal of type 2 diabetes mellitus (T2DM) and to evaluate the quality of the included studies. Methods literatures were obtained by searching PubMed, EMbase, Web of Science, BIOSIS Preview and Cochrane Library. Chinese literatures were obtained through CNKI, WanFang Data, SinoMed and VIP Database; The collection and screening studies were conducted in strict accordance with inclusion/exclusion criteria. The methodological quality and reporting quality of the included studies were evaluated using SYRCLE's risk of bias tool for animal studies (SYRCLE) and Animal Research: Reporting In Vivo Experiments guidelines 2.0(ARRIVE2.0). Outcomes，such as body weight (BW), fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA) were meta-analyzed and evaluated by Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results Twenty studies were included, including male mice (9) or rats (11). T2DM models have been developed mainly in two ways: high-fat diet and/or combined with streptozotocin (STZ) injection (15 articles), genetic modification (5 articles). Exercise and interval intensity are measured using VO2 max, maximum speed and slope, with 1-4.5 minutes of exercise and 15 second -3 minutes of interval, and the training duration was 8-13 weeks with 3-5 times of training a week. The SYRCLE’s result was mainly uncertain；None of the single items or the single studies assessed by ARRIVE 2.0 appeared complete. Standardized mean difference (SMD) combined the effect size of outcomes showed that compared with the sedentary control group, the heterogeneity was all large, and there are significant differences in FBG, HOMA. Very low quality of all evidence assessed by GRADE. Conclusions The effect of HIIT on blood glucose control is clear, but the influencing factors are complex, the risk of bias is high, the quality of reporting is low, the source of heterogeneity in outcomes is complex, and the quality of evidence is extremely low, which make its reliability and validity are questioned. It is recommended to use ARRIVE2.0 as a guide to increase the integrity and transparency of research information and improve research quality through experimental protocol registration and attachments.
分类： 生物学 >> 动物学 提交时间： 2018-12-25 合作期刊: 《动物营养学报》
摘要： 本研究旨在研究甜菜碱和L-肉碱对蒙寒杂交羊生长性能、屠宰性能、器官发育及脂肪沉积的影响。试验采用单因素试验设计，选取体重为（29.0±0.4） kg的蒙寒杂交羊270只，随机分为3组，每组3个重复，每个重复30只羊。对照组（CON组）饲喂基础饲粮，甜菜碱组（BN组）和L-肉碱组（L-CN组）分别在基础饲粮中添加1‰甜菜碱和0.4‰ L-肉碱。预试期15 d，正试期40 d。结果表明：1）L-CN组平均日采食量显著低于CON组和BN组（P0.05）。2）各组之间宰前活重、胴体重、屠宰率、眼积面积以及胴体脂肪含量值均无显著性差异（P>0.05）。3）各组之间内脏器官发育指标均无显著性差异（P>0.05）。4）L-CN组大肠重量及其所占宰前活重比例显著低于CON组（P0.05）。5）BN组和L-CN组总脂肪重量及其占宰前活重比例均显著低于CON组（P0.05）。由此可见，饲粮添加甜菜碱和L-肉碱均降低了蒙寒杂交羊的脂肪沉积量，而且主要降低了尾部脂肪的重量，提示我们甜菜碱和L-肉碱对蒙寒杂交羊降低体脂有一定的作用。
分类： 心理学 >> 应用心理学 分类： 计算机科学 >> 计算机应用技术 提交时间： 2018-03-05
摘要： [目的] 利用微博大数据探索熬夜和焦虑、抑郁情绪的关系。 [方法] 本研究根据微博用户在夜间的活动状态, 把100万活跃用户分为熬夜组和非熬夜组，比较两组用户在所发微博中出现的体现焦虑和抑郁情绪的相关词词频。 [结果] 独立样本t检验结果显示，熬夜组的焦虑相关词词频显著高于非熬夜组，t=36.86，p<0.001；熬夜组的抑郁相关词词频显著高于非熬夜组，t=49.71，p<0.001。 [局限] 词频分析与用心理测量量表测量抑郁和焦虑的情感无法完全等同，基于大数据的词频分析虽然提供了一种高效的分析方法，但不能完全替代严格的心理测量。 [结论] 入睡时间过晚会影响睡眠质量；熬夜人群更容易受到焦虑和抑郁情绪的困扰。
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