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1. chinaXiv:201711.02427 [pdf]

Discovery of multiple lead compounds as M2 inhibitors through the screening of a focused library of scaffold-hops

Wenhui Hu; Shaogao Zeng; Chufang Li; Zhiyuan Li; Ling Chen
Subjects: Biology >> Ecology

It is urgent to discover new anti-influenza drugs considering the threat of so called swine flu and Spanish flu. Though Adamantane derivatives are the only M2 inhibitors as anti-influenza virus A drugs, they are limited to use in the US due to drug resistant. Herein we reported that multiple lead compounds as M2 inhibitors were rapidly generated through the screening of focused library designed with scaffold-hopping strategy based on Amantadine.

submitted time 2017-11-17 Hits1215Downloads653 Comment 0

2. chinaXiv:201711.02428 [pdf]

Discovery of Multiple Lead Compounds as M2 Inhibitors through the Focused Screening of a Small Primary Amine Library

Wenhui Hu; Shaogao Zeng; Chufang Li; Yanling Jie; Zhiyuan L; Ling Chen
Subjects: Biology >> Ecology

The discovery of new anti-influenza drugs is urgent, particularly considering the recent threat of swine flu. Although amantadine derivatives are the only M2 drugs for influenza virus A, their use is limited in the US due to drug resistance. Here we report the discovery of multiple M2 inhibitor lead compounds that were rapidly generated through focused screening of a small primary amine library which was designed using a scaffold-hopping strategy based on amantadine.

submitted time 2017-11-17 Hits1183Downloads649 Comment 0

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