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1. chinaXiv:202104.00023 [pdf]

动脉粥样硬化ApoE-/-小鼠模型尿液蛋白质组学变化探究

华元瑞; 孟文书; 魏静; 刘永涛; 高友鹤
Subjects: Biology >> Biochemistry

心血管疾病是当今世界第一大致死因素,动脉粥样硬化是其重要病理基础,其早期诊断具有重要意义。尿液更利于积累和反应机体生理状态的变化且不受到稳态机制的调节,是疾病早期生物标志物的良好来源。本文通过高脂饮食诱导ApoE-/-小鼠5个月构建动脉粥样硬化动物模型,选取七个时间点收集实验组及正常饮食对照组c57BL/6小鼠尿液样品,使用蛋白质组学分析方法,进行自身对照和组间对照。自身对照结果表明高脂饮食1周前后尿液蛋白质组差异显著,同时多种差异蛋白被报道过与动脉粥样硬化相关或可作为其生物标志物。组间对照结果表明差异蛋白GO分析得出的生物学过程能够对应疾病发生发展的进程。两种对照方式得到的差异性化学修饰也多被报道与该疾病进程相关。实验证明了尿液蛋白质组学有敏锐监测机体变化的潜力,为寻找动脉粥样硬化早期生物标志物提供了可能。

submitted time 2021-04-08 Hits2Downloads2 Comment 0

2. chinaXiv:202104.00024 [pdf]

A Hybrid Algorithm for the Equal Districting Problem

Yunfeng Kong
Subjects: Geosciences >> Geography

The equal districting problem (EDP) arises in applications such as political redistricting, police patrol area delineation, sales territory design and some service area design. The important criteria for these problems are district equality, contiguity and compactness. A mixed integer linear programming (MILP) model and a hybrid algorithm are proposed for the EDP. The hybrid algorithm is designed by extending iterative local search (ILS) algorithm with three schemes: population-based ILS, variable neighborhood descent (VND) local search, and set partitioning. The performance of the algorithm was tested on five areas. Experimenta-tion showed that the instances could be solved effectively and efficiently.

submitted time 2021-04-08 Hits0Downloads0 Comment 0

3. chinaXiv:202104.00022 [pdf]

老年人的消极交往与心理健康:实证、理论与展望

徐潞杰; 张镇
Subjects: Psychology >> Applied Psychology

积极交往和消极交往分别会对老年人的心理健康产生有利和不利影响,然而,探讨消极交往的负面作用及其机制的研究相对较少。目前研究主要涉及消极交往的类型(社会隔离、丧偶或离婚)、来源(配偶、子女或朋友)及强度,并探讨感知评估、自尊的中介作用及性别、婚姻、受教育水平等变量的调节作用。社会情感选择理论、优劣势整合理论、社会交换理论及镜中我理论在一定范围内对消极交往的负面作用做出了合理解释。采取“原谅”或“认知疏远”的应对策略能有效缓解消极交往的负面影响。未来研究应进一步考察不同文化背景及社会网络背景下消极交往对老年人心理健康的影响,同时加强对消极交往的理论研究和线上研究,并关注相关的干预研究。

submitted time 2021-04-07 Hits104Downloads48 Comment 0

4. chinaXiv:202104.00021 [pdf]

“One-to-three” droplet generation-based digital microfluidics for parallel immunoassay.docx

Kai, Jin; Chenxuan, Hu; Siyi, Hu; Jinhua, Li; Hanbin, Ma
Subjects: Biology >> Bioengineering

In digital microfluidics, droplet generation is the fun, as the basis for a series of droplet manipulations including mixing, separation, dispensing, etc., has always been the focus in the field of digital microfluidics. Currently, the performance of DMF-based droplet splitting is highly influenced by the ratio of electrode size and the gap between the upper and lower plates. Here we propose a "one to three" droplet splitting method. In "one to three" spitting method, a pair of opposite electrowetting forces are applied to the droplet. As the electrowetting force is applied on the splitting position, a middle child droplet and two mother liquid droplets generate. The aspect ratio of child droplet is close to 1:2. "One to three" spitting method is then applied to magnetic beads immunoassay. Magnetic beads are retained in child droplets under small magnetic force with high magnetic bead washing efficiency. Simultaneous detection of five B-type natriuretic peptide analyte samples are performed on a single chip within 10 minutes. Correlation coefficient (R2) of the calibration curve was 0.9942, and the detection limit was less than 5pg/mL. This unique method of digital microfluidic droplet splitting has great potential in other application fields.

submitted time 2021-04-07 Hits82Downloads34 Comment 0

5. chinaXiv:202104.00020 [pdf]

Bacterial and viral therapies of cancer background, mechanism and perspective

董庆霖
Subjects: Medicine, Pharmacy >> Preclinical Medicine

Bacterial and viral therapies of cancer are highly promising, yet their mechanisms are incompletely understood, hindering their improvement and application. In this paper, We (1) review briefly the genesis and progress of bacterial and viral therapies of cancer, (2) compare and evaluate the proposed mechanisms of bacterial and viral therapies and present the unifying mechanism that bacterial and viral therapies of cancer mainly take advantage of the immune response of cancer cells to bacteria and viruses and the ability of host immune system to recognize and eliminate the responsive cancer cells, and (3) provide a perspective on the exploitation of non-human and non-animal bacteria and viruses, particularly protist-infecting bacteria and viruses and bacterial virus (bacteriophage), for cancer therapy.

submitted time 2021-04-06 Hits94Downloads39 Comment 0

6. chinaXiv:202104.00003 [pdf]

心理病理学网络理论、方法与挑战

陈琛; 王力; 曹成琦; 李根
Subjects: Psychology >> Statistics in Psychology

对于精神障碍这一概念的理解,传统DSM–ICD分类诊断系统和研究领域标准RDoC均基于潜变量视角,认为精神障碍的症状由其潜在共同原因所致。这2种观点都忽略了症状间的相互作用。不同于分类和维度视角,Borsboom在2008年对精神障碍的概念化提出了的全新视角——心理病理学网络理论。此理论的核心观点是症状之间的动态因果关系构成了精神障碍。基于心理病理学网络理论的网络分析方法,主要以结合EBIC的glasso算法估计症状间的偏相关网络,并通过网络中节点中心性与网络连接性等指标,来考查精神障碍症状的不同特性。近几年来,研究者发现心理病理学网络分析方法在对症状间因果关系的推断、核心症状的识别和网络结构的可靠性与可重复性方面仍面临一些挑战。这些挑战为心理病理学网络理论与方法指明了未来可能的发展方向。

submitted time 2021-04-03 Hits389Downloads122 Comment 0

7. chinaXiv:202104.00004 [pdf]

QZNs: Quantum Z-numbers

Deng, Jixiang; Deng, Yong
Subjects: Computer Science >> Integration Theory of Computer Science

Because of the efficiency of modeling fuzziness and vagueness, Z-numbers play an important role in real practice. However, Z-number and its existing fuzzy operations are defined in the real number field, which lacks the ability to process the quantum information in quantum environment. It is reasonable to generalize Z-number into its quantum counterpart. In this paper, we propose quantum Z-numbers (QZNs), which are the quantum generalization of Z-numbers. In addition, seven basic quantum fuzzy operations of QZNs and their corresponding quantum circuits are presented and illustrated by numerical examples. Moreover, based on QZNs, a novel quantum multi-attributes decision making (MADM) algorithm is proposed and applied in medical diagnosis. The results show that, with the help of quantum computation, the proposed algorithm can make diagnoses correctly and efficiently.

submitted time 2021-04-02 Hits156Downloads68 Comment 0

8. chinaXiv:202104.00005 [pdf]

Taxonomic revision of the holotype of Proboselaphus watasei Matsumoto, 1915 (Bovidae, Artiodactyla) from Chuanyu area, China

NISHIOKA Yuichiro; KOHNO Naoki; KUDO Yuichiro
Subjects: Biology >> Zoology

A taxonomic revision of Proboselaphus watasei Matsumoto, 1915 (Bovidae, Artiodactyla) from the Pleistocene of Chuanyu area, China demonstrates that this genus and species names are invalid. The holotype with a skull and mandibles was recently rediscovered in the fossil collection by Nobuo Naora, which is housed in the National Museum of Japanese History, Chiba Prefecture, Japan. Proboselaphus watasei was described as a closely-related species to living nilgai, or Boselaphus tragocamelus, in South Asia, based on general characteristics of pecorans, such as small bony horn-cores and hypsodont cheek teeth. However, the cranial and dental morphologies re-examined in the present study clearly show that the holotype has cervid-specific characteristics: e.g., the fronto-parietal surface curving dorsally, the basioccipital with a triangular outline, and molars with isolated anterior and posterior lobes. The molars of the holotype are comparable to those of Cervus unicolor, in having strong accessary structures (or spurs, cingulums/cingulids, and styles/stylids), and are as large as those of Cervus cf. C. unicolor from the Pleistocene deposits in southern China. This taxonomic change suggests that any crown-boselaphins had not dispersed into East Asia since the Pleistocene.

submitted time 2021-04-02 From cooperative journals:《古脊椎动物学报》 Hits122Downloads54 Comment 0

9. chinaXiv:202104.00006 [pdf]

Climate change and evolution of early lagomorphs (Mammalia): a study perspective based on new materials of Ordolagus from Nei Mongol (northern China)

Chiara ANGELONE; ZHANG Zhao-Qun
Subjects: Biology >> Zoology

The Early Oligocene is a critical time for global climate changes in the Cenozoic. This epoch witnessed severe mammalian faunal turnovers known as “Grande Coupure” in Europe and “Mongolian Remodelling” in Asia. However, insights about morphological changes in Oligocene mammal lineages have not been explored in detail. One of the least diversified groups of recent mammals, lagomorpha, is globally common in the fossil records, especially in Asia. During the Oligocene, many Eocene archaic lagomorph taxa died out and were replaced by more advanced forms. New findings from Nei Mongol and re-examination of the specimens from older collections enabled a revision of a common Asian lagomorph genus, Ordolagus, which possibly has a close affinity with the Middle–Late Eocene genus Gobiolagus. In Nei Mongol, we recognized the presence of Ordolagus during the basal Early Oligocene. Comparisons with coeval and slightly older lagomorph taxa from Asia and North America show that Ordolagus attained some salient tooth morphological characters (i.e., development of anteroconid on p3, full hypselodonty of cheek teeth, and lingual connection of trigonid and talonid on p4–m2), which are also the key features of modern leporids. The appearance of those morphologic features in Ordolagus is coeval to major global or regional climatic changes. Further investigations on Asian early lagomorphs compared with the study of other small mammals and local climatic factors will be essential to refine the role of lagomorphs as palaeoclimatic proxies.

submitted time 2021-04-02 From cooperative journals:《古脊椎动物学报》 Hits122Downloads53 Comment 0

10. chinaXiv:202104.00007 [pdf]

An Upper Miocene “Hipparion fauna” locality sandwiched by basalts in Hanjiaying, Nei Mongol

WANG Qian;LIU Yan;WANG Li-Hua; Mikael FORTELIUS; ZHANG Zhao-Qun
Subjects: Biology >> Zoology

Here we report a Hipparion fauna locality discovered in between two basalt layers near Hanjiaying Village, Jining District, Wulanchabu City, Nei Mongol. K-Ar isotopic dating of the lower and upper level of the basalt constrains the age of the fauna from 7.2 to 6.8 Ma. Compared with classical Hipparion fauna from northern China, the Hanjiaying fauna is closer to those from Baode of Shanxi, Siziwang Banner of Nei Mongol and the Linxia Basin of Gansu. It is similar to the Loc. 43, 44 and 49 from Baode by faunal composition, confirming their age to be ~7.0 Ma rather than 5.5 Ma. The high similarity with the fossils from Wulanhua, Siziwang Banner, Nei Mongol, verified the age of Wulanhua fauna at about 7 Ma. Compared with faunas from the Linxia Basin, Gansu, it is more similar to those from the upper part of the Liushu Formation, especially the Yangjiashan fauna. Based on the faunal composition and their tooth morphology, the Hanjiaying fauna could be included in the “Gazella dorcadoides” fauna, which is supposed to be at the west paleobiome in northern China during the Late Miocene.

submitted time 2021-04-02 From cooperative journals:《古脊椎动物学报》 Hits81Downloads34 Comment 0

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