分类: 光学 >> 量子光学 提交时间: 2023-02-19
摘要: Non-Hermitian systems with anti-parity-time ($\mathcal{APT}$) symmetry have revealed rich physics beyond conventional systems. Here, we study optomechanics in an $\mathcal{APT}$-symmetric spinning resonator and show that, by tuning the rotating speed to approach the exceptional point (EP) or the non-Hermitian spectral degeneracy, nonreciprocal light transmission with a high isolation ratio can be realized. Accompanying this process, nonreciprocal group delay or advance is also identified in the vicinity of EP. Our work sheds new light on manipulating laser propagation with optomechanical EP devices and, in a broader view, can be extended to explore a wide range of $\mathcal{APT}$-symmetric effects, such as $\mathcal{APT}$-symmetric phonon lasers, $\mathcal{APT}$-symmetric topological effects, and $\mathcal{APT}$-symmetric force sensing or accelerator.
分类: 药物科学 >> 药物设计 提交时间: 2024-05-13
摘要: As key oncogenic drivers in non-small-cell lung cancer (NSCLC), various mutations in the epidermal growth factor receptor (EGFR) with variable drug sensitivities have been a major obstacle for precision medicine. To achieve clinical-level drug recommendations, a platform for clinical patient case retrieval and reliable drug sensitivity prediction is highly expected. Therefore, we built a database, D3EGFRdb, with the clinicopathologic characteristics and drug responses of 1,339 patients with EGFR mutations via literature mining. On the basis of D3EGFRdb, we developed a deep learning-based prediction model, D3EGFRAI, for drug sensitivity prediction of new EGFR mutation-driven NSCLC. Model validations of D3EGFRAI showed a prediction accuracy of 0.81 and 0.85 for patients from D3EGFRdb and our hospitals, respectively. Furthermore, mutation scanning of the crucial residues inside drug-binding pockets, which may occur in the future, was performed to explore their drug sensitivity changes. D3EGFR is the first platform to achieve clinical-level drug response prediction of all approved small molecule drugs for EGFR mutation-driven lung cancer and is freely accessible at https://www.d3pharma.com/D3EGFR/index.php.
分类: 天文学 >> 天文学 提交时间: 2023-02-19
摘要: As the demand of astronomical observation rising, the telescope systems are becoming more and more complex. Thus, the observatory control software needs to be more intelligent, they have to control each instrument inside the observatory, finish the observation tasks autonomously, and report the information to users if needed. We developed a distributed autonomous observatory control framework named Remote Autonomous Control System 2nd, RACS2 to meet these requirements. The RACS2 framework uses decentralized distributed architecture, instrument control software and system service such as observation control service are implemented as different components. The communication between components is implemented based on a high-performance serialization library and a light-weighted messaging library.The interfaces towards python and Experimental Physics and Industrial Control System (EPICS) are implemented, so the RACS2 framework can communicate with EPICS based device control software and python-based software. Several system components including log, executor, scheduler and other modules are developed to help observation. Observation tasks can be programmed with python language, and the plans are scheduled by the scheduler component to achieve autonomous observation.A set of web service is implemented based on the FastAPI framework, with which user can control and manage the framework remotely.Based on the RACS2 framework, we have implemented the DATs telescope's observation system and the space object observation system.We performed remote autonomous observation and received many data with these systems.