Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract: The tightening policy of market regulation for food ingredients and novel foods produced by genetically modified microorganisms has hindered the development of the bio-economy. Here, the comparative studies have been conducted on the market regulations of food ingredients and novel foods produced by biomanufacturing in EU, USA, Japan, and China. These countries are all very concerned about the regulation of food ingredients and novel foods from biomanufacturing, however, they adopt quite different polices. EU is cautious, USA is positive, and Japan is less cautious. Over the past decades, China has been tightening the approval of food ingredients and novel foods produced by genetically modified microorganisms. At present, the whole world is actively responding to the supervision and access of new food ingredients and foods produced by new technologies. It is suggested that a positive application and approval path should be established, unified, and simplified for promoting the marketing of new products in China.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-19 Cooperative journals: 《中国科学院院刊》
Abstract: One main objective of metabolic engineering is to rewire the metabolic network for efficient production of biochemicals. Due to the complexity of cellular metabolic networks, it is often not straightforward to identify the proper modification targets from thousands of metabolic genes. Therefore, a time-consuming trial & error process is often required for the successful development. Aided by computational modeling of large-scale metabolic networks, one can design optimal pathways for synthesis of objective products, reducing the uncertainty of development and thus accelerating the strain construction process. In this short text, we give brief introduction to metabolic engineering design methods from two aspects: how to modify an organism to produce new chemicals with higher yields, and how to improve the cellular adaptation to the changing process conditions by integrating gene circuits. The computer aided design approach together with automated genome edition technologies, will greatly enhance the efficiency of the construction of artificial cell factories.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-19 Cooperative journals: 《中国科学院院刊》
Abstract: In the field of synthetic biology research, the massive scale of trial-and-error experiments in engineering goes far beyond the traditional labor-intensive research paradigm, so it needs a transformative engineering research platform. With the introduction of various types of intelligent equipment to meet the production needs, engineering platforms carry out a large-scale of customization and research paradigm innovation, to realize the remote customization, offsite design, and economic scale production of organisms. Engineering platforms can accumulate experience and knowledge quickly, and serve as the scientific basis for the predictive synthesis of organisms. This article will introduce some cases and development trends of engineering platforms, as well as upstream and downstream institutions for synthetic biology research.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-19 Cooperative journals: 《中国科学院院刊》
Abstract: Plant-derived natural products (PNPs) have been widely used in pharmaceutical and neutracuetical fields. Currently, extracting PNPs from their original plants is the main method to produce them. However, this extracting method is environmentally unfriendly, unsafe, and inefficient. Based on synthetic biology, construction of artificial cell factories for production of PNPs provides an alternative way. In this review, we focus on research progress for microbial production of terpenoids, alkaloids, and phenylpropanoids to give a brief introduction of construction of artificial cell factories for production of PNPs.