分类： 药物科学 >> 药物化学 提交时间： 2024-02-07
Hong-Ru Wang
Yang Jin
Ruo-Nan Sun
Li-Gong Yao
Jian-Hua Xia
Yun Huang
San-Hong Liu
Wei-Dong Zhang
Xu-Wen Li
摘要： A new cembranolide, namely, sinupendunculide A (1), along with eight known related compounds (29), was isolated from the South China Sea Soft coral Sinularia pendunculata. The structure of sinupendunculide A (1) was established by extensive spectroscopic analysis and X-ray diffraction experiments. In a bioassay, anti-colorectal cancer (CRC) activity was performed, and the results showed that several compounds exhibited cytotoxicity against RKO cells, and a preliminary structure-activity relationship was analysed. Meanwhile, the most effective compound 7 was proven to increase reactive oxygen species levels, which promoted cell apoptosis and inhibited cell proliferation.
分类： 药物科学 >> 药物化学 提交时间： 2024-02-07
摘要： Two new cladiellin-type diterpenoids (1 and 2), and four known related compounds 3-6, were isolated from the South China Sea soft coral Cladiella krempfi. Compound 2 is the third example of cladiellins of an unusual peroxy group at C-6 position in C. krempfi. The structures and absolute configurations of the new compounds were established by extensive spectroscopic analysis, X-ray diffraction, and/or chemical correlation. In bioassay, all the compounds were evaluated for the cytotoxicity and the EGFR inhibitory activity. Molecular docking experiment was conducted to study the structure-activity relationship of cladiellin-type diterpenoids on EGFR inhibitory activity.
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