The discovery and anti-colorectal cancer activities of cembranolides from the South China Sea soft coral Sinularia pendunculata

Subjects: Pharmaceutical Science >> Medicinal Chemistry submitted time 2024-02-07

Hong-Ru Wang Yang Jin Ruo-Nan Sun Li-Gong Yao Jian-Hua Xia Yun Huang San-Hong Liu Wei-Dong Zhang Xu-Wen Li

Abstract： A new cembranolide, namely, sinupendunculide A (1), along with eight known related compounds (2–9), was isolated from the South China Sea Soft coral Sinularia pendunculata. The structure of sinupendunculide A (1) was established by extensive spectroscopic analysis and X-ray diffraction experiments. In a bioassay, anti-colorectal cancer (CRC) activity was performed, and the results showed that several compounds exhibited cytotoxicity against RKO cells, and a preliminary structure-activity relationship was analysed. Meanwhile, the most effective compound 7 was proven to increase reactive oxygen species levels, which promoted cell apoptosis and inhibited cell proliferation.

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