Pulse radiolysis and laser flash photolysis study of balofloxacin

Subjects: Nuclear Science and Technology >> Nuclear Materials and Techniques submitted time 2023-06-18 Cooperative journals: 《Nuclear Science and Techniques》

XU Yulie LIU Yancheng LI Haixia ZHANG Peng TANG Ruizhi CAO Xiyan WANG Wenfeng

Abstract： Pulse radiolysis studies of the reactions between balofloxacin (BFX) and e_aq^‒ , hydroxyl radical (˙OH), and N₃^· were carried out to investigate the photosensitive toxicity of BFX. The BFX radical anion formed in the reaction of BFX with e_aq^‒ was located at 380 nm. The transient species formed in the reaction of BFX with ˙OH radical were located in the region of 370 nm to 580 nm, with a maximum λ_max at 390 nm. The BFX radical cation was obtained by reacting BFX with N₃˙, and showed an absorption band at around 365 nm. The UV-Vis absorption of the BFX was found to be clearly dependent on pH. The pK_a value of BFX was estimated to be 6.0±0.2. Under neutral conditions, the rate constants of BFX reacting with N₃˙ and e_aq^‒ were determined to be 1.3×10¹⁰ dm³·mol^‒1·s^‒1 and 1.4×10¹⁰ dm³·mol^‒1·s^‒1, respectively.

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