Subjects: Chemistry >> Applied Chemistry submitted time 2024-01-23
Abstract： Addressing the drawbacks of conventional formula design methods, such as being cumbersome, time-consuming, resulting in material wastage, and yielding poor optimization outcomes, a novel approach for optimizing the formula of aluminum alloy cleaners is proposed by combining the Latin Hypercube Design (LHD) algorithmwith the Multilayer Perceptron (MLP) neural network. Leveraging the comprehensive exploration of parameter space using the LHD algorithm and the efficient modeling capability of the MLP neural network, the formula for aluminum alloy cleaners was successfully optimized. With the optimized formula, the cleaning efficiency increased from 87.9% to 98.24%, and the corrosion rate decreased from 4.2 mg to 0.3 mg. Regression analysis of the model's predicted data against experimental data yielded a correlation coefficient greater than 0.98, demonstrating consistency between predicted and experimental data.
Peer Review Status:
Awaiting Review
Subjects: Chemistry >> Applied Chemistry submitted time 2020-03-05
Abstract： [Objective] Synthesis of potential neroprotective agent catalpol perpropionylated derivative (CP-6), and determination of the optimal microwav-assisted synthesis conditions. [Methods] CP-6 was synthesized by microwave-assisted synthesis (MCAS) using catalpol and propionyl anhydride as raw materials and pyridine as solvent and acid-binding agent. It was characterized by FT-IR, HRMS, NMR and assayed for neuroprotective activity by MTT method. [Results] When the molar ratio of propionic anhydride to catalpol is 18, the concentration of catalol in pyridine is 25 g/L, the reaction temperature of microwave reactor is 80 ℃, and the reaction time is 6 h, the yield of CP-6 can reach 98.51%. CP-6 has potential neroprotective activity."
Peer Review Status:Awaiting Review
Subjects: Chemistry >> Applied Chemistry submitted time 2017-10-17
Abstract： Phytochemical study on the aerial parts of Mikania micrantha led to the isolation of four new ent-kaurene diterpene glucosides, β-D-glucopyranosyl-15α-(3-hydroxy-3-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (1), β-D-glucopyranosyl-15α-(3-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (2), β-D-glucopyranosyl-15α-(2-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (3), β-D-glucopyranosyl-15α-(3-methyl-2-butenoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (4), along with a known one, β-D-glucopyranosyl-15α-(3-hydroxy-3-methylbutanoyloxy)-ent-16-kauren-19-oate (5). Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–4 are a group of C-9 hydroxylated ent-kaurene diterpene glucosides which is relatively rare in nature. These compounds selectively showed in vitro antibacterial activity against four assayed Gram-(+) and three Gram-(-) bacteria. In addition, the in vitro growth inhibitory activity of these compounds against human cancer cell lines Hela, A549, HepG-2 and MCF-7, were also tested.
Peer Review Status:Awaiting Review
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