分类: 计算机科学 >> 计算机科学的集成理论 提交时间: 2022-11-27 合作期刊: 《数据智能(英文)》
摘要: Online marketers make efforts to sell more products to their customers to increase turnover. One way to sell more products is to ensure that products belonging to the same scene are offered together. As such, it is beneficial to categorize products into different groups and tag them to particular, defined scenes. The mechanism of building relationships between products and scenes is called scene-based knowledge system construction. The construction of a scene-based knowledge system is usually based on business operators expert knowledge and past experiences, which often causes product categorization to be inaccurate. Hence, in this paper, we discuss the importance and necessity of constructing a scene-based knowledge system, analyze it from a business perspective, and discuss its challenges.
分类: 动力与电气工程 >> 工程热物理学 提交时间: 2017-06-26 合作期刊: 《热科学学报》
摘要: The advantage of high efficiency, low SFC (Specific Fuel Consumption), ultra-high bypass ratio turbofan engine attracts more and more attention in modern commercial engine. The intermediate turbine duct (ITD), which connects high pressure turbine (HPT) with low pressure turbine (LPT), has a critical impact on the overall performance of turbine by guiding flow coming from HPT to LPT without too much loss. Therefore, it becomes more and more urgent to master the technique of designing aggressive, even super-aggressive ITD. Much more concerns have been concentrated on the duct. However, in order to further improve turbine, LPT nozzle is arranged into ITD to shorten low pressure axle. With such design concept, it is obvious that LPT nozzle flow field is easily influenced by upstream duct structure, but receives much less interests on the contrary. In this paper, numerical method is used to investigate the effects of length of ITD with upstream swirl blades on LPT nozzle. Nine models with the same swirl and nozzle blades, while the length of ITD is the only parameter to be changed, will be discussed. Finally, several conclusions and advices for designers are summarized. After changing axial length of ducts, inlet and outlet flow field of nozzle differs, correspondingly. On the other hand, the shearing stress on nozzle blade (suction and pressure) surface presents individual feature under various inlet flow. In addition to that, "Clocking-like effect" is described in this paper, which will contribute much to the pressure loss and should be paid enough attention.
分类: 生物学 >> 生物物理学 >> 细胞生物学 提交时间: 2016-05-11
摘要: Membrane receptors at the surface of target cells are key host factors for virion entry; however, it is unknown whether trafficking and secretion of progeny virus requires host intracellular receptors. In this study, we demonstrate that dengue virus (DENV) interacts with KDEL receptors (KDELR), which cycle between the ER and Golgi apparatus, for vesicular transport from ER to Golgi. Depletion of KDELR by siRNA reduced egress of both DENV progeny and recombinant subviral particles (RSPs). Coimmunoprecipitation of KDELR with dengue structural protein prM required three positively charged residues at the N terminus, whose mutation disrupted protein interaction and inhibited RSP transport from the ER to the Golgi. Finally, siRNA depletion of class II Arfs, which results in KDELR accumulation in the Golgi, phenocopied results obtained with mutagenized prME and KDELR knockdown. Our results have uncovered a function for KDELR as an internal receptor involved in DENV trafficking.