分类： 地球科学 >> 地理学 提交时间： 2019-06-20 合作期刊: 《干旱区科学》
摘要： Aerial photographs and 3-D laser scans of a 90-m high star dune at the Crescent Moon Spring scenic spot in Dunhuang, China, are used to investigate the changes in dune morphology on timescales from months to decades. The result revealed that relative-equilibrium airflow strength in three wind directions of northeast, west and south was an important condition for the stability of star dunes with limited migration. Transverse and longitudinal airflows exerted a crucial impact on variation processes of star dune morphology. Controlled by transverse airflows, the easterly winds, the east side was dominated by wind erosion; and strong deposition occurred on the south-south-east arm with a maximum deposition rate of 0.44 m/a in the 46-a monitoring period, causing the east side becoming steep and high. Controlled by longitudinal airflows, the westerly winds, the west-north-west side was mainly eroded and the north arm migrated from west to east with a rate of 0.30 m/a, causing the dune slope becoming gentle and elongate. The local air circulation (southerly winds) exerted a significant impact on the development process of the star dune. Due to the influence of human activities, the south side present surface processes from a concave profile to a convex profile in 46 a, which is a potential threat to the Crescent Moon Spring. The results indicate that rehabilitating the airflow field at most is a crucial strategy to the protection of Crescent Moon Spring from burial. Opening up the passage of easterly, westerly and southerly winds through intermediately cutting the protection forest, demolishing the enclosed wall and changing the pavilion into a porous pattern have been suggested to protect the Crescent Moon Spring from burial.
分类： 生物学 >> 生物物理学 >> 细胞生物学 提交时间： 2016-05-15
Zhang, Dongdong
Zhang, Weimin
Li, Dan
Fu, Ming
Zhan, Qimin
Zhang, Dongdong
Zhang, Weimin
Li, Dan
Fu, Ming
Zhan, Qimin
Zhang, Dongdong
Chen, Runsheng
Zhan, Qimin
摘要： GADD45A is a TP53-regulated and DNA damage-inducible tumor suppressor protein, which regulates cell cycle arrest, apoptosis, and DNA repair, and inhibits tumor growth and angiogenesis. However, the function of GADD45A in autophagy remains unknown. In this report, we demonstrate that GADD45A plays an important role in regulating the process of autophagy. GADD45A is able to decrease LC3-II expression and numbers of autophagosomes in mouse tissues and different cancer cell lines. Using bafilomycin A(1) treatment, we have observed that GADD45A regulates autophagosome initiation. Likely, GADD45A inhibition of autophagy is through its influence on the interaction between BECN1 and PIK3C3. Immunoprecipitation and GST affinity isolation assays exhibit that GADD45A directly interacts with BECN1, and in turn dissociates the BECN1-PIK3C3 complex. Furthermore, we have mapped the 71 to 81 amino acids of the GADD45A protein that are necessary for the GADD45A interaction with BECN1. Knockdown of BECN1 can abolish autophagy alterations induced by GADD45A. Taken together, these findings provide the novel evidence that GADD45A inhibits autophagy via impairing the BECN1-PIK3C3 complex formation.
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