A Psychophysiological Model of State Switching in Bipolar Disorder Based on the Salience Network

Subjects: Psychology >> Other Disciplines of Psychology submitted time 2024-05-06

Zhang, Gui Zhong, Yuan

Abstract： Bipolar disorder is a highly burdensome and refractory mental disorder, affecting individuals, families, and society. The challenge in bipolar disorder is that the treatment targeting the depressive state often carries the risk of inducing manic state, and vice versa, with the frequency of these alternating cycles often indicating the severity of the illness. Therefore, reducing the frequency of state switching in bipolar disorder patients and gradually achieving a stable state are crucial for effective treatment. The purpose of this study is to propose a psychophysiological model of bipolar disorder state switching. Considering the remarkable potential of the salience network in brain switching, we anchor a model on the functionality of the salience network to analyze and demonstrate the pathways involved in bipolar disorder state switching within the framework of psychophysiological. By focusing on the salience network, this model provides valuable insights into the treatment, patterns of development, and pathophysiological mechanisms of bipolar disorder.
 

Peer Review Status:Awaiting Review

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