Subjects: Psychology >> Other Disciplines of Psychology submitted time 2022-09-08
Abstract：
Early life stress (ELS) has been used to describe a broad spectrum of adverse and stressful events, including childhood trauma occurring during neonatal life, early and late childhood, and adolescence. Childhood is a vulnerable time point for stressful events due to an immature brain, which increases the risk of psychopathology in later life. However, to date, studies have focused almost exclusively on adolescents and adults, and little is known about the relationship between ELS and the structural and functional brain changes in children. Here, we adopted a multimodal approach combining voxel-based morphometry (VBM) and functional connectivity (FC) to examine the neural substrates of ELS in children aged 9~12 years.
A total of 139 children were recruited for this study. For each participant, the ELS level was assessed and an 8-minute rs-fMRI scan was performed using a 3T Trio scanner. Participants with unqualified data were excluded, resulting in a final sample of 78 participants (39 females; mean age = 10.18). For statistical analysis, we used the gray matter volume (GMV) and FC to explore the brain structural and functional correlates of children’s ELS and then used a machine learning method to investigate whether and how structural connectivity profiles in predefined brain networks can predict ELS levels. Additionally, exploratory analyses were performed to investigate potential sex differences and age characteristics in GMV and FC associated with children’s ELS.
VBM analysis showed that greater ELS was associated with a larger GMV in the left medial orbitofrontal cortex, right insular cortex, left superior temporal gyrus, and left supplementary motor area. Subsequently, we used these clusters as seed regions to analyze the correlation between FC and stress in children. We found that greater ELS was associated with lower insular-inferior parietal lobule (IPL) connectivity. The results were not influenced by sex, age, total intracranial volume, or head motion. Furthermore, the predictive analysis of machine learning reported that the sensorimotor, frontoparietal, salience, visual, and cerebellar networks could marginally predict ELS scores. Finally, exploratory analyses showed that there were no significant sex differences in the GMV or FC associated with ELS and that significant correlations of ELS with the GMV of the inferior occipital gyrus were mainly manifested in 9-year-old children.
Using VBM and FC analyses, we detected structural and functional brain alterations associated with ELS in children aged 9~12 years. Specifically, the VBM analysis mainly reflected that children with high ELS may have abnormal emotional and cognitive functions, such as hypersensitivity to emotional stimuli and over-monitoring of their own behavior. In addition, FC analysis indicated that aberrant interaction of internal and external information may contribute to high ELS in childhood. This study not only provides unique insights into the neural substrates of ELS but may also help identify children who are susceptible to ELS within the general population, which may be advantageous for early prevention strategies and interventions for children.
Peer Review Status:
Awaiting Review
Subjects: Psychology >> Cognitive Psychology submitted time 2022-08-01
Abstract： In our complex social environments, life situations are ever-changing. When dealing with these changes, there is no one-size-fits-all response or regulatory strategy suitable for all situations. Emotion regulation flexibility (ERF)—a framework for understanding individual differences in adaptive responding to ever-changing life contexts—emphasizes that individuals can flexibly deploy and adjust emotion regulation strategies according to specific characteristics of stressful situations in daily life. To achieve regulatory efficacy, it is important that one can utilize a balanced profile of ER strategies and select strategies that fit well with particular stressful situations. Specifically, using multiple ER strategies in daily life, rather than relying on only single-strategies, would indicate higher ERF. Additionally, based on leading models of strategy-situation fit, certain ER strategies are more appropriate for high versus low intensity stressful events. For instance, distraction involves with shielding oneself from negative stimuli and replacing them with irrelevant things, which may have a greater regulatory effect in high-intensity negative situations. Conversely, strategies such as reappraisal, which involves the processing of negative situations through deep cognitive change, may be more effective in lower-intensity negative situations and as a cornerstone of longer-term ER. We used the experience-sampling method (ESM) to quantify individual’s ERF; more specifically we assess participants for 1) having more or less balanced ER strategy profiles and 2) showing greater strategy-situation fit, in regard to the use of distraction versus reappraisal in the regulation of high-intensity versus low-intensity negative life events. To test the adaptive value of ERF on negative emotions and mental health, we investigated the influence of ERF on depressive and anxiety symptoms in two samples. We hypothesized that individuals with a more balanced profile of ER strategy use and a great level of strategy-situation fit would have higher levels of mental health, indicated by low levels of anxiety and depressive feelings. In sample 1, two hundred eight college students finished the ESM procedure (2859 beeps). Intensity of negative situations was measured by self-reported negative feelings for the time points where participants reported an adverse event. Simultaneously, we assessed participants’ use of two ER strategies (i.e., distraction and reappraisal). Considering the negative impact of COVID-19 on people’s daily life, we collected another sample (sample 2, 3462 beeps) with one hundred people who lived in Hubei Province, where Wuhan was in lockdown during the severe phase of COVID-19 (March 7-13, 2020). We measured intensity of negative situations (by averaging individuals’ negative feelings), as well as the use of two ER strategies at corresponding time points. After completing the ESM procedure, the participants were asked to fill out a series of emotional health questionnaires, including Beck Depression Inventory-II, Beck Anxiety Inventory and Spielberg State Anxiety Scale. Multilevel models were used to fit the covariation between the use of distraction versus reappraisal ER strategies and the intensity of negative events. Additionally, we used multiple level regression models to test whether high level of strategy-situation fit would result in lower negative feelings. To test whether a single-strategy preference would lead to higher levels of anxiety and depressive feelings compared to a multiple-strategy preference, latent profile analyses (LPA) was used. Results from the LPA indicated that individuals with preferences for rumination and express suppression reported higher levels depression and anxiety than individuals with a multi-strategy preference. In the multilevel models, results of the two independent samples both suggested individuals who were more inclined to use a higher level of distraction in response to high-intensity negative situations (e.g., adverse events or during COVID-19) and use higher levels of reappraisal during low-intensity situations (i.e., high level of ERF) reported lower levels of anxiety and depressive feelings. On the converse, individuals who tended to use more distraction in low intensity situations and more reappraisal in high intensity situations, (i.e., those showing lower ERF) reported a higher level of negative feelings. Together, our findings revealed a negative relationship between ERF and mental health problems in two samples, suggesting that having balanced ER profiles and flexibly deploying strategies in specific life contexts may have adaptive value in facilitating positive mental health. This work deepens our understanding of the interaction between ER strategies and situational demands, paving the way for future intervention research to help alleviate negative emotions associated with affective disorders or the experience of major traumatic events (such as epidemics, earthquakes, etc.).
Peer Review Status:Awaiting Review
Subjects: Psychology >> Cognitive Psychology submitted time 2022-07-04
Abstract： Updating outdated memories with newly acquired information is an important ability. To ensure less interference from outdated memories, one either trims old memory traces or differentiates between novel and old memories. Although the age-related decline in episodic memory has been well-established, aging effect on episodic memory updating and its underlying cognitive mechanisms are less understood. Memory differentiation and memory interference may act as two different mechanisms that underlie episodic memory updating. To bridge this research gap, we investigated the different updating memory patterns in young and older adults. Furthermore, we intended to clarify the updating differences in item and source memory, which are the two essential elements embedded in episodic memory. By implementing an adapted AB-AC memory updating paradigm, we posited that young adults would comparably attain A-B and A-C memory. In contrast, older adults would experience C memory intrusions in the A-B memory test, indicating memory interference. We examined episodic memory updating for a sample of 30 young and 30 older adults randomly selected from the university and neighboring community. On Day 1, participants learned 36 naturalistic A-B pairings and completed the encoding test immediately after learning. On Day 2, participants first reviewed the A-B pairs before being introduced to 36 novel A-C pairings (where C’s items or sources were different from those in B), following which they completed the Day 2 encoding test. Finally, all the participants returned to the laboratory and completed the A-B and A-C tests on Days 3 and 5. To elucidate the updating memory patterns between the two age groups, we classified their responses into target, competitor, and lure categories to test the group-level differences in memory updating.
Peer Review Status:Awaiting Review
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