Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2023-10-14
Abstract: As an indispensable trace element in human body, copper plays an important role in various physiological and biochemical reactions. Cuproptosis is a newly proposed regulatory cell death mode, which is different from the known apoptosis, pyroptosis, necroptosis and ferroptosis. Recently, dysregulation of copper homeostasis has been observed in a variety of cancers. Therefore, targeting copper for cancer therapy may become a new strategy and a new idea. This study will systematic review the fundamental properties of copper, related diseases caused by copper overload or deficiency, the association between cuproptosis and cancer, and the treatment of diseases related to copper disorders.
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2023-10-11
Abstract: Ferroptosis is a type of regulated cell death (RCD) dependent on iron and reactive oxygen species, which is mainly characterized by the accumulation of intracellular lipid peroxides and is different from apoptosis, necrosis and autophagy. It has been found that iron death is closely related to tumor cells, and the therapeutic effect of therapeutic drugs on tumors can be improved by inducing iron death in tumor cells. In this paper, we summarize the mechanism of iron death and the latest progress of iron death and tumor-related studies, with the aim of providing reference for further understanding of the mechanism between iron death and tumors, and providing new ideas and targets for the treatment of related diseases.
Peer Review Status:Awaiting Review