Subjects: Biology >> Biochemistry submitted time 2020-02-08
Yingxia Liu
Yang Yang
Cong Zhang
Fengming Huang
Fuxiang Wang
Jing Yuan
Zhaoqin Wang
Jingxiu Li
Jianming Li
Cheng Feng
Zheng Zhang
Lifei Wang
Ling Peng
Li Chen
Yuhao Qin
Dandan Zhao
Shuguang Tan
Lu Yin
Jun Xu
Congzhao Zhou
Abstract： The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia (ALB), lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%) and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, ALB, CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.
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