Subjects: Mechanics >> Applied Mechanics submitted time 2023-03-20 Cooperative journals: 《应用力学学报》
Abstract： The creep mechanical model of pile foundation is established based on the creep displacement ofpile foundation and its equivalent time-dependent soil settlement theory.The bearing mode of pile founda-tion and its correlation with load on the top of pile , the settlement displacement and time-dependent char-acteristics of pile foundation under the coresponding bearing mode are studied.The results show that fric-tion end bearing pile in creep stratum is affected by the rheological characteristics of soil , and total dis-placement of pile foundation presents significant time-dependent characteristics , which is dominated by thecreep characteristics of soil.The applicability of model and theoretical method in creep formation is veri-fied by the engineering examples. The viscoelastic theoretical solution can be used not only to predict long-term displacement of pile foundation in stable creep stratum , but also to calculate the failure of pile foun-dation in other creep stratum.
Subjects: Mechanics >> Applied Mechanics submitted time 2023-03-20 Cooperative journals: 《应用力学学报》
Abstract： Based on mechanical characteristics of pile foundation in layered anisotropic soft soil layer , byconstructing the virtual cylindrical equivalent model and using the layered summation method , the theoreti-cal solutions of pile axial deformation and pile bottom settlement displacement are deduced , and calculationmethod of pile foundation settlement displacement suitable for arbitrary layered anisotropic stratum andload conditions is established.The settlement and displacement characteristics of pile foundation in layeredanisotropic stratum,the phenomenon of interface mutation and its evolution law with engineering and geo-logical factors are studied. The results show that there is a zero axial force horizontal plane in the pile sec-tion or the soil at the bottom of the pile with the depth varying with the load and engineering geological parameters. When the depth of the zero axial force plane is less than the length of the pile foundation , thepile foundation is in the friction bearing mode , and the settlement displacement of the pile foundation isequal to the deformation of the pile at the upper part of the section;On the contrary , the pile foundation isin the common bearing mode of friction and pile end, and the settlement displacement of pile foundation isequal to the superposition of pile deformation and pile bottom settlement. 'The field test results verify thecorrectness of the theoretical method.The established layered model and theoretical method can easily sim-ulate the soft soil stratum with approximate horizontal distribution and its engineering geological parame-ters , and can be directly applied to the bearing design and calculation of pile foundation in any layered an-isotropic stratum.
Subjects: Biology >> Biochemistry submitted time 2020-02-28
Abstract： 肺癌作为一种严重威胁人类生命健康的疾病，尽管治疗方法种类较多，但如何把握治疗时机，为患者确定最有效的治疗用药仍然是一个难题。尿液蛋白质组可以敏感的反映机体的生理变化，有希望反映药物治疗后机体的病理或生理变化。为了研究晚期肺癌患者使用不同的药物进行治疗时其尿液蛋白质组的变化情况，通过收集晚期肺癌患者治疗前后的不同时间的尿液样本，使用液相色谱联用质谱（LC-MS / MS）来检测其尿蛋白组的变化。比较结果发现，当不同的患者使用不同药物治疗后，差异蛋白的变化各不相同，其差异蛋白反映的生物学过程变化和患者的临床表现变化较为一致。这项研究结果表明，（1）能够通过尿蛋白的变化反映不同药物治疗后患者的病理生理变化；（2）当不同患者使用相同药物治疗后，尿蛋白的变化能够反映出患者体内不同的病理生理变化，且和患者的临床病情评估结果较为一致。这些发现有可能为辅助临床治疗提供重要信息。
Peer Review Status:
Awaiting Review
Hits
YES
Hits
Downloads
Comment