Subjects: Biology >> Biochemistry submitted time 2022-03-03
Abstract：
Abstract：
[Objective] To investigate the effect of hypoxia on urine proteome in rats,and to find the changes of urine protein related to hypoxia stress.
[Methods] In this study,liquid chromatography-mass spectrometry (LC-MS/MS) was used to screen the urine differential proteins of rats with 12 and 24h hypoxia and analyze the biological pathway to observe the changes of urine protein in rats with acute hypoxia stress.
[Results] We found that the urine proteome could clearly distinguish the normoxic and hypoxic samples, and the differential proteins were also enriched in biological pathways related to hypoxic stress,such as antioxidant stress,glycolysis,complement and coagulation cascade.
[Conclusions] Urine proteome can reflect the significant changes after acute hypoxic stimulation, which is helpful for the detection of hypoxia.
Peer Review Status:
Awaiting Review
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