Prefrontal dysfunction and a monkey model of schizophrenia

分类： 生物学 >> 生物物理学 >> 神经科学 提交时间： 2016-05-12

Ma, Yuan-Ye Mao, Ping Cui, Ding Zhao, Xu-Dong Ma, Yuan-Ye Ma, Yuan-Ye

摘要： The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyl-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral impairment might be a specific indicator of schizophrenia-related cognitive impairment.

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