Cortisol responses to chronic stress in adult macaques: Moderation by a polymorphism in the serotonin transporter gene

分类： 生物学 >> 生物物理学 提交时间： 2016-05-11

Qin, Dongdong Rizak, Joshua Feng, Xiaoli Yang, Shangchuan Fan, Xiaona Hu, Xintian Qin, Dongdong Rizak, Joshua Feng, Xiaoli Yang, Shangchuan Fan, Xiaona Hu, Xintian Lue, Longbao Hu, Xintian Rizak, Joshua Qin, Dongdong Chen, Lin Yang, Lichuan Yang, Lichuan

摘要： Accumulating evidence has shown that a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the association between stress and depressive symptoms. However, the exact etiologies underlying this moderation are not well understood. Here it is reported that among adult female rhesus macaques, an orthologous polymorphism (rh5-HTTLPR) exerted an influence on cortisol responses to chronic stress. It was found that females with two copies of the short allele were associated with increased cortisol responses to chronic stress in comparison to their counterparts who have one or two copies of the long allele. In the absence of stress, no differences related to genotype were observed in these females. This genetic moderation was found without a genetic influence on exposure to stressful situations. Rather it was found to be a genetic modulation of cortisol responses to chronic stress. These findings indicate that the rh5-HTTLPR polymorphism is closely related to hypothalamus pituitary adrenal (HPA) axis reactivity, which may increase susceptibility to depression in females with low serotonin transporter efficiency and a history of stress. (C) 2014 Elsevier B.V. All rights reserved.

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