Feasibility of medical radioisotope production based on the proton beams at China Spallation Neutron Source

分类： 物理学 >> 核物理学 提交时间： 2024-03-10

Bing Jiang Binbin Tian Hantao Jing Qifan Dong

摘要： Theutilization of a proton beam fromthe China Spallation Neutron Source (CSNS) for producingmedical radioisotopes is appealingowing toits high current intensity and high energy. The medical isotope production based on the proton beam at the CSNS is significantfor the development of futureradiopharmaceuticals, particularly for the α-emitting radiopharmaceuticals.The production yield and activity of typical medical isotopes wereestimated using theFLUKA simulation. The results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II ishighly suitable for proof-of-principle studies of most medical radioisotopes. In particular, this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes, such as 225Ac, whose theoretical production yield can reach approximately57 Ci/week. Based on theseresults, we provideperspectives on the use ofCSNS proton beams to produce radioisotopes for medical applications.

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