Current Situation of Potentially Inappropriate Medication in Older Cancer Patients and Strategies to Address It

Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-07-27 Cooperative journals: 《中国全科医学》

XU, Man AN, Zhuoling ZHANG, Yuhui MA, Zhuo

Abstract： An increasing number of studies have demonstrated that potentially inappropriate medication（PIM）occurs commonly in elderly patients with cancer，with higher prevalence of PIM than general elderly，which may lead to adverse effects on prognosis of the patients. Therefore，it is necessary to conduct a systematic and comprehensive review of previous studies to provide support and reference for future studies. PubMed，CNKI and Wanfang Data were systematically searched to summarize and analyze the screen tools of PIM，prevalence of PIM，main drugs involved，influencing factors and the relationship between PIM and adverse outcomes. The results showed that the prevalence of PIM varied when different PIM screen tools were used in older patients with cancer，and the list of medications commonly used for supportive care that are of concern in older patients provided by the NCCN Guidelines for Older Adult Oncology（2020.v2） demonstrated advantages in providing individualized medication management for elderly patients with cancer. Polypharmacy，age，and comorbidities were significantly associated with the development of PIM. Benzodiazepines and analgesics are commonly used as high-risk drugs in elderly patients with cancer. PIM may be associated with higher mortality rates，drug interaction rates，adverse event rates，emergency and hospital readmission rates in elderly patients with cancer. It is hoped that this article will provide a reference for conducting studies related to PIM in elderly patients with cancer in China and provide support for promoting the safe and rational use of medication in elderly patients with cancer.

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