Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2018-10-26 Cooperative journals: 《协和医学杂志》
Abstract： Venous thromboembolism is a serious complication after orthopedics arthroplasty, which could result in significant loss of patients’satisfaction of artificial joint. In some extreme cases, it also could lead to deaths of patients owing to respiration and circulation failure. The most important and effective method to prevent this complication is anti-coagulation therapy preoperative, that could greatly reduce the incidence of venous thromboembolism after arthroplasty. Anticoagulant drugs, such as low molecular weight heparin, Xa factor inhibitors, are first choices for anti-coagulation therapy after arthroplasty. These drugs have certain effect and low risk of bleeding postoperative, but there are still some deficiencies, including expensiveness, injections and so on. Aspirin is a historical antiplatelet drug, now some guides and researches suggest it also can be a choice for prevention venous thromboembolism after arthroplasty. In these researches, they found aspirin has similar prophylactic effect and safety compared to anticoagulant drugs of prevention of venous thromboembolism after arthroplasty. Aspirin is cheaper, economical, and it could be oral application, that is convenient for patients. Some researchers also believe aspirin has lower bleeding rates compared with anticoagulant drugs. In terms of drugs doses, low dose aspirin could have sufficient preventive effect for venous thromboembolism, and that could reduce the gastrointestinal adverse reactions of aspirin. In conclusion, aspirin is a new choice for prevention of venous thromboembolism after arthroplasty
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-27 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the relationship between polymorphisms of surfactant protein D (rs3088308 and rs721917) and the susceptibility to silicosis. Methods This case-control study included 125 silicosis patients and 125 individuals exposed to industrial dust but without silicosis (control group), who were strictly matched with the case group for age, gender, work type and cumulative length of dust exposure. The rs3088308 and rs721917 polymorphisms of surfactant protein-D were detected in all the participants using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The frequencies of T/T, T/A and A/A genotypes of surfactant protein-D rs3088308 locus were 22.2%, 71.2% and 5.6% in the case group, significantly different from the frequencies of 17.6%, 58.4% and 24.0% in the control group, respectively (P< 0.05). The frequencies of C/C, C/T and T/T genotypes of rs721917 locus were 17.6%, 56.8% and 25.6% in the case group, similar to the frequencies of 15.2% , 60.0% and 24.8% in the control group, respectively (P>0.05). Conclusion Surfactant protein-D rs3088308 polymorphism is significantly associated with silicosis, and the T allele may be a risk factor for silicosis in individuals exposed to industrial dust.
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