Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-12-28 Cooperative journals: 《中国全科医学》
Abstract： Background The modified COVID-19 Yorkshire Rehabilitation Scale（C19-YRSm） has been shown to be useful to assess and monitor patients in post-COVID-19 syndrome in developed countries. However，its reliability and validity in the Chinese population remains unclear. Objective To translate the C19-YRSm into a Chinese version（C19-YRSm-C），and test the reliability and validity of the Chinese version. Methods After obtaining the approval of the translation and use authority of the C19-YRSm from MANOJ SIVAN's team at the University of Leeds，United Kingdom，the research team translated the C19-YRSm and formed the C19-YRSm-C after translation，back-translation，and cross-cultural adaptation，according to the Translation and Cross-cultural Adaptation Procedure. From May 1 to 7，2023，a simple random sampling method was used to select post COVID-19 patients from the "Wen Juan Xing" platform sample pool as the study subjects. The General Information Questionnaire and the C19-YRSm-C were used to survey them. 13 experts were invited to evaluate the content validity of the scale. The C19-YRSm-C was subjected to item analysis，reliability and validity analysis. Results A total of 512 questionnaires were distributed and 370 valid questionnaires were recovered，with a valid recovery rate of 72.3%. The results of item analysis showed that the CR values of the items ranged from 6.589 to 22.725（P<0.001），and the item-total correlation coefficients of the scale ranged from 0.547 to 0.806 （P<0.001）. For reliability，the Cronbach's α coefficient，Guttman Split half coefficient and test-retest reliability of the C19-YRSm-C was 0.881，0.837 and 0.816，respectively. For content validity，the item-level content validity index（I-CVI） of the C19-YRSm-C ranged from 0.692 to 1.000，and the scale-level validity index（S-CVI） was 0.914. The results of confirmatory factor analysis（CFA） showed that the fitting indicators of the initial model were undesirable. After the establishment of a covariance correlation between error variables e12 and e13 according to the indication prompts，the fitting indicators of the modified model were within the acceptable range except for the adjusted goodness of-fit index （AGFI）. The results of discriminant validity analysis showed that the differences in scores for the 4 subscales of the C19-YRSm-C among post-COVID-19 patients with different chronic disease history and cumulative number of COVID-19 showed statistically significant differences（P<0.05）. The differences were statistically significant when comparing the scores of the 3 subscales in addition to other symptoms before and after COVID-19 infection（P<0.05）. Conclusion The C19-YRSm-C has good reliability and validity，with good applicability in Chinese population，which can be used to assess and monitor the rehabilitation status of post COVID-19 patients in China.
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract： Inhibition performance of a complex inhibitor of bis-quaternary ammonium and thiourea (with mass fraction 1∶1) for the serious corrosion of P110 steel in simulated oilfield produced waters was studied by means of techniques of mass loss, electrochemical frequency modulation (EFM) and coupled multielectrode array sensors (CMAS). Experimental results indicate that this inhibitor could inhibit P110 steel from CO2 corrosion efficiently. The inhibition efficiency was up to 95.31% when the concentration of inhibitor was 150 mg/L at 60 ℃. The inhibition efficiency decreased at 90 ℃, however, the inhibitor could eliminate the pitting corrosion of P110 efficaciously. EFM and CMAS techniques could monitor the corrosion process of the steel and evaluate the effectiveness of the inhibitor. The deviation from theoretical value of causality factor of EFM could reveal the effectiveness of the addition of inhibitor, i.e. the inhibitor could protect P110 from pitting corrosion. The results of CMAS showed that the prevention of pitting corrosion could be attributed to the adsorbing of inhibitor on the steel surface to relieve the concentrated distribution of cathodic and anodic currents.
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract： none
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract： none
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the effect of γ-secretase inhibitor (N-[N-(3,5-difluorophenacetyl)-l -alanyl]-S-phenylglycine t-butyl ester, DAPT) on hyperoxia-induced brain white matter injury in mice. Methods Three-day-old C57BL/10J mouse pups were divided into air control (C) group, control+DAPT (10 mg/kg, injected intraperitoneally) group, hyperoxia group (exposed to 80% oxygen for 48 h), and hyperoxia+DAPT group. The brain and body weights of the mice were measured at postnatal days 3, 5, 12, and 28. Real-time PCR was used to detect Notch intracellular domain (NICD) mRNA expression in the brain after modeling, and the expressions of NG2 and myelin basic protein (MBP) were detected by double-labeled immunofluorescence assay to verify the oligdendrocycle type at postnatal day 12. The mice in each group were bred until postnatal day 28 for Morris water maze test. Results The brain and body weights were significantly decreased in mice in hyperoxia group compared to the control mice, but increased significantly after DAPT treatment (P<0.05). Real-time PCR showed that a 48-hour hyperoxia exposure significantly increased NICD mRNA expression in the brain (P<0.05), which was decreased by co-treatment by DAPT (P<0.05). Hyperoxia also resulted in enhanced NG2 expression and lowered MBP expression in the brain (P<0.05). Compared with the control mice, the mice exposed to hyperoxia showed prolonged escape latency (P<0.05) and spent less time in the target quadrant with a lowered number of passing through the virtual platform (P<0.05). All these parameters were significantly improved by co-treatment with DAPT. Conclusion Specific inhibition of Notch signaling pathway activation in the brain by the γ-secretase inhibitor DAPT can ameliorate white matter injury and learning and memory impairment in newborn mice with hyperoxia exposure.
Subjects: Materials Science >> Materials Science (General) Subjects: Geosciences >> Marine Sciences submitted time 2017-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract：运用开路电位、交流阻抗、阳极极化曲线和电化学频率调制技术研究了304不锈钢在不同温度（60~90℃）及不同海水（一级反渗透淡化海水、天然海水、1.6倍浓缩海水）中的点蚀行为。结果表明，304不锈钢在一级反渗透淡化海水中随着温度的升高点蚀敏感性增加；在发生点蚀前的钝化状态下，304不锈钢在一级反渗透淡化海水中比在海水中腐蚀严重；304不锈钢的点蚀敏感性随Cl-浓度的升高而增加；304不锈钢在80℃下的一级反渗透淡化海水中随浸泡时间的延长，腐蚀速率逐渐增大，且在浸泡1d时即有发生点蚀的倾向，在第10d时已经发生了点蚀。
Subjects: Materials Science >> Materials Science (General) Subjects: Geosciences >> Marine Sciences submitted time 2016-11-12 Cooperative journals: 《中国腐蚀与防护学报》
Abstract：以两种Al-Zn-In-Mg-Ti系牺牲阳极为研究对象，采用了开路电位、恒电流极化、循环伏安曲线、交流阻抗法等电化学测试方法，研究了牺牲阳极在不同电位下的极化性能。结果表明：阳极开路电位下由于氧化膜的存在导致阳极不易溶解，当对阳极施加外加电流后，双电层电容逐渐增大，极化电阻逐渐减小，氧化膜逐渐破裂；随着极化电位的增大，阳极发出电流迅速增大，此时极化电阻逐渐减小，最后基本稳定不变；极化电阻较小的阳极材料有着较好的电化学性能，这与4d加速试验的评价结果是吻合的。
Subjects: Materials Science >> Materials Science (General) Subjects: Geosciences >> Marine Sciences Subjects: Energy Science >> Chemistry of Energy submitted time 2016-11-11 Cooperative journals: 《中国腐蚀与防护学报》
Abstract：为研究X65碳钢在模拟油田采出水中的阴极保护规律，采用极化曲线、恒电位阴极极化和失重法，并结合SEM、EDS、XRD分析产物的形貌、成分和结构，研究了不同保护电位下碳钢的保护效果和机制。结果表明：该环境中，自腐蚀条件下的X65碳钢发生严重腐蚀，失重速率大，坑蚀严重；从-800mV到-1000mV的保护电位对X65碳钢的腐蚀均有明显抑制效果；-800mV阴极保护电位下碳钢表面无良好的钙质沉积层形成，-900mV下表面能生成牢固致密的钙质沉积层，有效降低保护电流密度，-1000mV下沉积层容易因析氢反应而鼓泡脱落；相比于海洋环境，碳钢在油田采出水中的析氢电位偏正，沉积层中不含氢氧化镁。
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