Subjects: Library Science，Information Science >> Utilization of Information submitted time 2024-04-01
Abstract： Purpose/significance By utilizing the Data Citation Index (DCI) database, this article explores the reuse features and influencing factors of scientific data in the field of high-energy physics. These findings serve as a point of reference and support, facilitating the promotion of data sharing and citation standardization in China. Moreover, these contribute to the augmentation of both value and influence of scientific data. Method/process This article adopt statistical regression methods to analyze the basic and citation features of the DCI database. For the reuse features and influencing factors, the analysis includes three dimensions: scientific data attribute features, reuse features, and correlation between attribute and reuse features. Result/conclusion The research findings reveal that the publication volume of scientific data in the field of high-energy physics is exhibiting an increasing trend. However, the proportion of missing data fields is relatively high. The reuse of high-energy physics scientific data is significantly influenced by publication modes and disciplinary categories. These result in the extremely uneven distribution of citation frequency. High-level scientific data are more likely to be reused. Moreover, the standardization of scientific data sharing and citation needs further enhancement. Finally, we propose an optimization and improvement path for high-energy physics science data reuse based on this findings.
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Awaiting Review
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-27 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the expression of microRNA-107 (miR-107) and its functional role in hepatocellular carcinoma (HCC). Methods The gene chip data of HCC obtained from the Gene Expression Omnibus (GEO) database and the Cancer Genome Atlas (TCGA) database were used to analyze the expression levels of miR-107 in liver cancer. Twenty-two pairs of fresh surgical specimens of HCC and adjacent tissues and 53 paraffin-embedded specimens of HCC were examined for miR-107 expression by qRT-PCR. The correlation of the expression levels of miR-107 with the clinicopathologic characteristics of the patients were analyzed. The role of miR-107 in regulating the proliferation of hepatocellular carcinoma cells were determined by MTT assay in Huh7 cells transfected with a miR-107 mimic or inhibitor. Results The expression levels of miR-107 were significantly up-regulated in HCC tissues as compared to the adjacent tissues (P<0.05) in positive correlation with the tumor size (P<0.032). Transfection with miR-107 mimics significantly promoted the cell proliferation (P< 0.0001) while miR-107 inhibitor inhibited the cell proliferation (P<0.0001). Conclusion The expression of miR-107 is upregulated in HCC tissues and its expression levels are correlated with HCC cell proliferation, suggesting its role as a potential oncogene in liver cancer.
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