Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-03-28 Cooperative journals: 《中国全科医学》
Abstract： Background Multimorbidity have become a major character in the course of chronic diseases that brings a challenge for public health in China. The development of multimorbidity research in China is in an early stage with fewer literature，and there is a lack of systematic and comprehensive literature analysis. Objective To conduct a bibliometric and visual analysis of research hotspots and evolutionary trends in the field of multimorbidity in China，grasp the research frontiers and development directions in the field，thereby providing a reference for future research directions. Methods CNKI（Chinese data source）and WOS（foreign data source） were searched for the literature in the field of multimorbidity researches published by Chinese researchers. CiteSpace software was used to analyze the spatial and temporal distribution of multimorbidity and explore the research hotspots and evolutionary trends in the field of multimorbidity by plotting the collaboration network map of institutions and co-occurrence map of keywords for researches in the field of multimorbidity published by Chinese researchers. Results The number of published literatures in the field of multimorbidity showed an increasing trend from 2002 to 2022. The top 5 Chinese keywords were “comorbidity （342）”“older adults（161）”“depression （155）”“chronic diseases （106）”“diabetes （94）”；and the top 5 English keywords were “prevalence （126）”“older adults （92）”“multimorbidity （91）”“health （75）” “disease（71）”. There were 4 development stages in the research development history of multimorbidity: The initial stage of research，the researchers focused on the comorbidity characteristics but did not define it in a uniform way；The second stage of research，the researchers focused on comorbidity and chronic disease in older adults，discovered the high prevalence of multimorbidity in the elderly population；The third stage of research，the domestic researches on multimorbidity developed rapidly，involving influencing factors，comorbidity patterns，polypharmacy，quality of life and debilitation；The fourth stage of research，the definition of multimorbidity is becoming clearer，showing a trend of research diversification. Conclusions Researches in the field of multimorbidity is becoming increasingly diversified. Researchers should focus on the prevention and treatment of complex multimorbidity，and construct health management strategies and community intervention programs for multimorbidity population in China.
Subjects: Environmental Sciences, Resource Sciences >> Other Disciplines of Environmental Sciences, Resource Sciences submitted time 2021-03-02 Cooperative journals: 《干旱区研究》
Abstract：合理改良河套灌区紧邻排干沟盐碱地，能够有效促进灌区盐碱地生态修复与农业可持续发展。结合描述性统计与主成分分析的方法，对河套灌区乌拉特灌域紧邻排干沟土壤盐碱化与肥力特征进行了分析。结果表明：（1）研究区土壤属于重度氯化物型盐化土；Mg2+为土壤盐化程度高的关键阳离子，Mg2+含量过高减缓了Na+的吸收速度，加剧了土壤碱化进程。（2）0~40 cm土层土壤碱化度在13.0%~28.6%之间，土壤碱化度高的原因包括两个方面：一方面是由于CaCO3不能阻止土壤吸附Na+，另一方面是因为土壤中Mg2+不能促进Na+吸附；土壤pH与碱化度、总碱度均存在正相关关系。（3）主成分分析结果表明，研究区可将土壤含盐量、Cl-、Ca2+、Mg2+、pH、总碱度和碱化度作为土壤盐渍化的主要特征因子。（4）研究区土壤钾素含量偏高，其他营养元素含量偏低。紧邻排干沟的土壤属于氯化物盐化土与碱化土复合型盐碱地，导致土壤具有土粒分散、湿时泥泞、不透气、不透水、干时硬结、耕性极差的特点；同时土壤养分偏低，应大量补充除钾素以外的其他土壤营养元素。该研究对于分析河套灌区紧邻排干沟盐碱土、制定合理土地利用政策与生态改良措施和实现区域可持续发展等方面具有重要作用。
Subjects: Geosciences >> Geography submitted time 2020-12-17 Cooperative journals: 《干旱区研究》
Abstract：以河套灌区下游乌拉特灌域为研究区，通过野外实测与室内试验分析相结合，采用传统统计与主成分分析方法探讨盐渍化土壤春季（4月）和秋季（10月）含盐量与盐分离子分布规律，明确影响土壤盐渍化的主导因子。结果表明：（1）春季（4月）和秋季（10月）土壤含盐量变化范围在0.55~70.78 g·kg-1，表层土壤含盐量平均值在7 g·kg-1以上，属于中度以上盐渍化土壤，有些土壤达到盐土程度。（2）表层土壤含盐量明显大于深层土壤，是深层的1.5~2倍，是盐分的积累层，属于盐分表聚型土壤。（3）各层土壤阳离子以Na+为主，占阳离子总量的47.19%，阴离子以Cl-为主，占阴离子总量的58.86%，研究区主要受到氯化物的影响，以钠盐为主，且春季土壤盐分含量明显高于秋季。主成分分析表明，前2个主成分的累积方差贡献率为86.44%，与第一主成分密切相关的是Na+、Cl-、TS、Ca2+、Mg2+，这5个指标与土壤盐渍化关系密切，代表了土壤盐渍化状况；在第二主成分因子变量中，K+与HCO3-具有较其他变量更高的载荷，K+与HCO3-通过影响土壤碱度进而在一定程度上影响土壤盐渍化。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the effect of liraglutide, an analogue of glucagon-like peptide-1, on the proliferation and migration of cardiac microvascular endothelial cells (CMECs) and explore the mechanism. Methods In vitro cultured CMECs of SD rats were purified by differential adhesion method and identified immunocytochemically using CD31 antibody and factor VIII. MTT assay was performed to assess the proliferation of the first-generation cells exposed to different concentrations (0-1000 nm/L) of liraglutide. Western blotting was used to detect the activation of PI3K/Akt and MAPK/ERK signaling pathways. BrdU fluorescent labeling and scratch assay were performed to observe the proliferation and migration of CMECs following liraglutide treatment, and PI3K/Akt and MAPK/ERK pathway inhibitors LY294002 and PD98059, respectively, were used to further confirm the role of these signaling pathways in regulating the proliferation and migration of CMECs. Results Immunocytochemical staining demonstrated a proportion of double positive cells exceeding 95%. The cells exhibited a logarithmic growth 48 h after plating. Liraglutide exposure concentration-dependently promoted the proliferation of CMECs with the optimal concentration of 100 nmol/L (P<0.05). Liraglutide exposure of the cells for 24 h significantly increased the levels of intracellular phosphorylated Akt and ERK (P<0.05), but pretreatment of the cells with Akt and ERK signaling pathway inhibitors 1 h before liraglutide obviously reversed such effect (P<0.05). BrdU and scratch assay showed that 100 nmol/L liraglutide significantly promoted the proliferation and migration of CMECs (P<0.05), but such effects were obviously suppressed by Akt and ERK inhibitors (P<0.05). Conclusion Liraglutide promotes the proliferation and migration of CMECs in vitro via PI3K/Akt and MAPK/ERK signaling pathways.
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