Subjects: Biology >> Botany >> Applied botany submitted time 2023-07-13 Cooperative journals: 《广西植物》
Abstract： Ardisia crenata var. bicolor is a common medicine used by Miao minority in Guizhou, which has the effects of clearing throat and benefiting pharynx, reducing swelling and relieving pain, dispelling wind and dehumidifying. In order to study the chemical constituents and anti-inflammatory activities of A. crenata var. bicolor roots, the 70% ethanol extact were separated and purified by silica gel, Sephadex LH-20 gel column chromatography, ODS reverse column chromatography and semi-preparative HPLC. The structures of the compounds were identified by spectral data of NMR, MS and published literatures. Using lipopolysaccharide(LPS)-activated RAW 264.7 cell line models in vitro, compounds 1-4 were evaluated for the inhibition against nitric oxide(NO) production. The results were as follows: Ten compounds were isolated from the ethanol extract and identified as 11-O-galloyl bergenin (1), 11-O-(4-O-methylgalloyl) bergenin (2), 11-O-vanilloylbergenin (3), 6-O-(4-hydroxy benzoyl) bergenin (4), 11-syringyl bergenin (5), 11-O-(3',4'-dimethylgalloyl)-bergenin (6), demethoxybergenin (7), micractinin A (8), monomethyl olivetol (9), and dibutyl phthalate (10). Among them, compounds 4, 8 and 9 were obtained from this genus for the first time. The results of anti-inflammatory activities in vitro were as follows: Compounds 1-4 could significantly inhibit NO release in RAW 264.7 cells (P < 0.01), and the inhibition rates of compounds at a concentration of 20 μmol·mL-1 were 67.09%, 66.50%, 59.83%, 36.47%, respectively. This study enriches the chemical constituents of this plant, clarify the material basis of its anti-inflammatory activities, verify the scientificity of its traditional usage, and provide new insight and scientific evidence for its rational development and utilization of the medicinal resources.
Subjects: Management Science >> Science ology and Management submitted time 2023-07-09 Cooperative journals: 《中国科学院院刊》
Abstract： Open science is thriving and driving a global paradigm shift in scientific research. Open science governance is designated to gradually increase the transparency and global participation in the process of scientific and technological progress, ensure low-cost openness around the world, accelerate the global dissemination and sharing of results, and improve the scientific and humanistic literacy of the people. With the development trend of open science becoming more and more powerful, a series of challenges emerge gradually. By analyzing and studying the open science governance framework model, it helps to further sort out the governance logic, clarify the governance subjects and governance mechanisms, which will effectively promote the construction of open science governance system, accelerate the development of science and technology, help China become one of the leaders of the global knowledge community in 2040–2050, and promote the realization of the strategic goal of becoming a world power in science and technology.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： The concept of bionics combines biology and engineering technology to provide people with new principles, methods, and ways to improve and create new equipment, promote technological innovation, and solve technical problems in the most flexible, efficient, reliable, and economical way. Although information technology continues to develop, it still faces many challenges in the era of big data and intelligence. With the explosive growth of massive data, the demand of storage, calculation, and analysis, and its energy consumption and efficiency challenges, information technology is urgently needed to find a new development direction. Inspired by biotechnology, it is becoming an international frontier research direction to find information technology innovation scheme from biological structure. As active new research fields, DNA data storage and neural morphological computation as well as related research are representative directions, which have broad future development prospects. Based on the development status and trend of these two research directions, this study attempts to analyze the motivation, trend, and prospect of information technology development inspired by biotechnology. The next two decades will be an important time window for the cross integration of life field and information field. By learning and simulating from life system, and drawing on the new ideas, principles and theories provided by biotechnology research, the information field will produce a number of subversive technologies and applications, and it will affect the entire academic and industrial sessions.
Subjects: Biology >> Botany >> Applied botany submitted time 2021-05-11 Cooperative journals: 《广西植物》
Abstract： The dried roots of Sophora tonkinensis were commonly used as the treatment of the throat and other infectious diseases. In order to identify its large polar antibacterial active components, silica gel column chromatography (CC), ODS CC and Sephadex LH-20 CC and semi preparative HPLC were used to isolate the chemical constituents from n-butanol fraction of S. tonkinensis. The antibacterial activities of the monomers against bacteria (Enterobacter faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli) and fungi (Candida albicans) were evaluated. The results showed ten compounds were isolated and identified as 2',4',7-trihydroxy-6,8-bis(3-methyl-2-butenyl)flavanone(1),genistin(2), 2-2',4'-dihydroxy-5,6-dioxomethylbenzofuran(3), maltol-β-D-glucopyranoside(4), leonuriside A(5),coniferylalcohol-9-O-β-D-glucopyranoside(6),glabrol(7),2-(2',4'-dihydroxy-phenyl)-8,8-dimethyl-10-(3-methyl-2-butenyl)-8H-pyrano[2,3-d]chroman-4-one (8), oxymatrine (9), piscidic acid (10). Among of them, compound 4-6 was isolated from the title plant for the first time, for our knowledge. Besides, biological activity test showed the potential antibacterial activities of compounds 1-3. It is worth mentioning that the minimum inhibitory concentration (MIC) value of compound 2 against Pseudomonas aeruginosa was 15.6 μg·mL-1, while the MIC of compound 3 against Candida albicans and Escherichia coli were 31.3 μg·mL-1.
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