Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2018-12-04 Cooperative journals: 《协和医学杂志》
Abstract：目的探讨加速康复外科胃癌患者术后不常规留置导尿管的可行性。方法回顾性分析2016年6月至2017年3月，南京总医院普通外科采用加速康复外科理念择期行胃癌根治术患者的临床资料。人选患者麻醉诱导期插人导尿管，手术结束时即刻拔除导尿管并以此时间为观察起始点，记录患者术后首次排尿时间、首次排尿量、重插尿管的比例，分析首次排尿延迟及重插尿管的危险因素。结果137例患者纳人本研究，其中男90例(65.7%)，女47例(34.3 %) ,平均年龄X58.9士10. 1)岁，术后首次排尿时间为(}5. 3士2. 1) h，首次自解尿量(298. 9101. 3 ) ml，重置尿管比例为11.7% (16/137);相比开腹组，机器人组自主排尿率高，诱导排尿率、重置导尿管及尿路刺激征发生率均较低(P均6 h组术中输液量较多、术中尿量较多、首次自解小便时间及首次下床活动时间均延迟(P均<0.01)。结论加速康复外科胃癌患者术后即刻拔除尿管是可行的，术中控制性输液、多模式镇痛是不常规留置导尿管的基础条件，机器人手术有利于患者术后早期恢复自主排尿
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-06-15 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To explore the expression of the family with sequence similarity 135 member B (FAM135B) and K(lysine) acetyltransferase 5 (KAT5) in esophageal squamous cell carcinoma (ESCC) in Uygur patients. Methods The expression of FAM135B and KAT5 in ESCC tissues and paired adjacent tissues from 40 Uygur patients were detected using Roche Benchmark XT. The correlation of FAM135B and KAT5 and their correlation with the clinicopathological characteristics of the patients were analyzed. Results The positivity rates of FAM135B and KAT5 in ESCC tissues were 92.50% (37/40) and 15.00%(6/40) in these patients, respectively. The ESCC tissues showed a significantly higher rate of strong FAM135B expression than the adjacent tissues［45.00% (18/40) vs 22.50% (9/40); χ2=4.528, P=0.033］, but the rates of negative KAT5 expression was similar between ESCC and adjacent tissues［85.00% (34/40) vs 87.50% (35/40); χ2=0.105, P=0.745］. Strong expressions of FAM135B in ESCC tissues and the paired adjacent tissues were well correlated (Kendall's coefficient = 0.707, P<0.001). In ESCC tissues, a strong expression of FAM135B showed a significant negative correlation with KAT5 expression (Kendall's coefficient=-0.946, P< 0.001). Neither FAM135B nor KAT5 expression was associated with the patients' gender, age, tumor site, tumor differentiation, invasion, lymph node metastasis and clinical stage (all P>0.05). Conclusion A strong expression of FAM135B may be an important molecular basis for the occurrence of ESCC in Uygur patients and plays its role by negatively regulating the expression of KAT5.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-21 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To detect the expressions of IL-17, IL-23, IL–22 and IL–11 in the intestinal mucosa of patients with ulcerative colitis (UC) and analyze their prognostic values. Methods Forty patients with active UC, 15 with UC in remission and 15 healthy subjects were examined for the expressions and distribution of IL-17, IL-23, IL-22, and IL-11 in the colorectal mucosausing immunohistochemistry. We further collected the data from 40 patients with routine therapy and regular follow-up and compared the expressions of those cytokines according to the condition of mucosal healing. Results The expressions of cytokines in patients with active UC were significantly higher than those in patients with remittent UC and healthy control subjects (IL-17: 0.0727±0.0037 vs 0.0354±0.0243 vs 0.0330±0.0045; IL-23: 0.1407±0.0068 vs 0.0865±0.0051 vs 0.0442±0.0137; IL-22: 0.0522±0.0045 vs 0.0259±0.0063 vs 0.0115±0.0061; IL-11: 0.0479±0.0022 vs 0.0365±0.0024 vs 0.0232±0.0009, P<0.05).The expression levels of IL-17, IL-23, and IL-22 increased significantly with the increase of the disease activity (IL-17: 0.0545±0.0072 vs 0.0786± 0.0051 vs 0.0847±0.0197; IL-23: 0.1112±0.0046 vs 0.1480±0.0089 vs 0.1644±0.0190; IL-22: 0.0307±0.0063 vs 0.0548±0.0071 vs 0.0719±0.0056, P<0.05). In patients with active UC, the expression levels of the 4 cytokines in the intestinal mucosa were positively correlated with the endoscopic activity grade (P<0.05), and IL-17 and IL-22 expression levels were also positively correlated with the histological grade (P<0.05). All the 4 cytokines were positively intercorrelated. The patients with low IL-17 expression (25.00% ) showed a significantly lower rate of poor mucosal healing than those with high IL-17 expressions (25% vs 67%, P<0.05). Conclusion The cytokines IL-17, IL-23, IL-22, and IL-11 all participate in the pathogenesis of UC and may serve as indicators for evaluating the inflammatory activity. The expression level of IL-17 can be a valuable indicator for predicting mucosal healing in UC patients after a short-term treatment.
Subjects: Geosciences >> Space Physics submitted time 2016-05-13
Abstract：偶极化锋面在观测统计以及个例分析中被广泛研究. 它最主要的特征是北向磁场(GSM坐标系下的B_z 分量)的突然增强, 并且之前B_z会出现短暂的减小. 观测结果显示偶极化锋面是一种地向传播、厚度只有离子回旋半径量级的结构, 并且通常伴随着强的瞬态电场、波动以及电流. 观测和模拟结果都表明当偶极化锋面通过卫星时, 测得的粒子通量在某一能量阈值以下下降, 而在该阈值以上的通量则上升. 锋面附近电子和离子的加速一直是这几年研究的热点. 尽管锋面附近粒子加速现象已经被广泛研究, 但是锋面后高能离子通量减少的机制还没有被探究清楚. 利用THEMIS(The History of the Events and Macroscale Interactions during Substorm)卫星观测到的偶极化锋面附近离子通量变化的情况, 我们将探究偶极化锋面附近离子的行为特征.
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