Subjects: Psychology >> Social Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： The neuropeptide, oxytocin (OT) has been established to play an important role in modulating social behavior and emotional processing which are of fundamental importance in our everyday life. Animal and human studies using multi-modal approaches have provided converging evidence for an important modulatory effect of exogenously administered OT on learning and memory. This effect of exogenous OT may be mediated via its receptors which are extensively distributed in key learning and memory brain networks, notably the dopamine reward pathway and limbic system. Whether OT has a facilitatory or inhibitory modulatory effect on learning and memory can be influenced by experimental paradigms and stimulus materials as well as where and when it is administered and at what dose. Future studies need to combine the respective advantages of animal models and human research and to employ standardized experimental protocols and treatment procedures to overcome current limitations in this field. Further research is also required to explore the therapeutic potential of OT for learning and memory dysfunction in psychiatric disorders.
Subjects: Psychology >> Cognitive Psychology submitted time 2021-07-11
Abstract： The neuropeptide, oxytocin (OT) has a very extensive impact on social behavior and emotional processing, including learning and memory that play a key role in our work and daily life. Animal and human studies using multi-modal technologies have provided converging evidence for an important modulatory effect of OT on learning and memory. This effect of OT may act via the binding of externally administered OT on OT receptors extensively distributed in key learning and memory brain networks namely the dopamine reward pathway and limbic system. The facilitatory or inhibitory effect of OT on learning and memory can be affected by experimental paradigms, stimulus materials, time point, dose and location of administration. In the future, it is necessary to combine the respective advantages of animal and human research, utilize standardized experimental protocols and treatment procedures to overcome current limitations in this field. Further effort should also be paid to exploring the application potential of OT in treatment of learning and memory deficits in psychiatric disorders. " " " " " "
Peer Review Status:
Awaiting Review
Subjects: Biology >> Virology submitted time 2020-02-14
Abstract： Abstract: In 2019, the 2019 novel Coronavirus (2019-nCoV) has caused the pneumonia outbreak in Wuhan (a city of China). In our previous study, the analytical results showed that both 2019-nCoV and SARS coronavirus belongs to Betacoronavirus subgroup B (BB coronavirus), but have large differences. The most important finding was that the alternative translation of Nankai CDS could produce more than 17 putative proteins, which may be responsible for the host adaption. The genotyping of 13 viruses using the 17 putative proteins revealed the high mutation rate and diversity of betacoronavirus. The present study for the first time reported a very important mutation in the Spike (S) proteins of BB coronavirus. By this mutation, 2019-nCoV acquired a cleavage site for furin enzyme, which is not present in the S proteins of all other BB coronavirus (e.g. SARS coronavirus) except the Mouse Hepatitis coronavirus (MHV). This mutation may increase the efficiency of virus infection into cells, making 2019-nCoV has significantly stronger transmissibility than SARS coronavirus. Because of this mutation, the packing mechanism of the 2019-nCoV may be changed to being more similar to those of MHV, HIV, Ebola virus (EBoV) and some avian influenza viruses, other than those of all other BB coronavirus (e.g. SARS coronavirus) except the Mouse Hepatitis coronavirus (MHV). In addition, we unexpectedly found that some avian influenza viruses acquired a cleavage site for furin enzyme by mutation as 2019-nCoV. Further studies of this mutation will help to reveal the stronger transmissibility of 2019-nCoV and lay foundations for vaccine development and drug design of, but not limited to 2019-nCoV.
Peer Review Status:Awaiting Review
Subjects: Biology >> Molecular Biology submitted time 2018-08-29
Abstract： "
Peer Review Status:Awaiting Review
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