Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-09-28
Song, Xiaochen
Zhang, Hui
Zhong, Sen
Tan, Xianjie
Ma, Shuiqing
Jin, Ying
Pan, Lingya
Wu, Ming
Cao, Dongyan
Yang, Jiaxin
Xiang, Yang
Abstract： Objective: The current treatment for early-stage neuroendocrine carcinoma of the cervix (NECC) mainly relies on radical hysterectomy and chemotherapy. The routine use of postoperative radiation is still in controversial. We want to evaluate the value of postoperative radiation in early-stage NECC.
Methods: A retrospective cohort study. Early-stage NECC patients from 2006 to 2022 in Peking Union Medical College Hospital were included. Depending on whether the patients received radiation therapy after surgery, they were divided into Postoperative non-radiation group (Group A) and Postoperative radiation group (Group B). We use Kaplan-Meier method to analyze the progression-free survival (PFS), overall survival (OS), recurrence and OS rate.
Results: Sixty-six cases were included, 32 (48.5%) in Group A and 34 (51.5%) in Group B. After 35 (range 12-116) months follow-up, 26 (39.4%) experienced recurrence. Compared with Group A, Group B had lower pelvic recurrence rate (12.5% vs 2.9%, p = 0.142), slightly higher distant recurrence rate (28.1% vs 44.1%, p = 0.177), and similar mortality rate (29.4% vs 31.3%, p = 0.871). Cervical stromal invasion ≥1/2 was more common in Group B (28.0% vs 63.0%, p = 0.012). Postoperative radiation in patients with cervical stromal invasion ≥1/2 showed an extended trend in PFS (33.9 months vs 47.9 months) and OS (40.7 months vs 70.0 months) but without statistical difference (p = 0.963, p = 0.636). Lymph-vascular space invasion (LVSI) is a high-risk factor for tumor recurrence (HR 9.13, p = 0.005), but radiation after surgery did not improve the PFS (51.5 months vs 48.8 months, p = 0.942) and OS (53.9 months vs 60.6 months, p = 0.715) in patients with LVSI.
Limitations: The limitations of this study are the retrospective nature and relative small sample size.
Conclusions: Postoperative radiation seems to prolong PFS and OS in patients with cervical stromal invasion ≥1/2. LVSI was a high-risk factor for tumor recurrence, but radiation after surgery in patients with LVSI seems have no survival benefits.
Peer Review Status:
Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2018-12-12 Cooperative journals: 《协和医学杂志》
Abstract：近年来，腹腔镜微创手术在早期宫颈癌中被广泛应用。既往回顾性研究显示，微创手术具有术中出血少、住院时间短、术后恢复快的优点，同时总生存期与传统开腹手术无差别。但N Engl J Med在2018年10月30日刊登的一项前瞻性多中心随机对照临床试验和一项回顾性流行病学研究结果均显示，微创手术增加了早期宫颈癌的死亡率。这两项研究结果虽不能完全否定腹腔镜在早期宫颈癌治疗中的作用，但应引起术者的重视与反思:规范化的肿瘤治疗原则是基础，手术路径的选择应以患者、疾病和术者技术特点为依据。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-27 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To explore the race- and gender-specific distribution characteristics of rs1891385A/C and rs10975519C/T polymorphism of interleukin-33 (IL-33) gene in Zhuang and Han populations. Methods The polymorphisms of rs1891385A/C and rs10975519C/T of IL-33 gene in 283 subjects from Guangxi Zhuang Autonomous Region were analyzed with single base extension (PCR-SEB) and DNA sequencing to analyze the differences in their distribution frequencies between genders and between Zhuang and Han populations. Results Three genotypes (AA, AC and CC) were found in rs1891385A/C with frequencies of 64.3% , 32.5% and 3.2% , respectively. The genotype and allele frequencies of rs1891385A/C in this Guangxi population showed no significant difference between Zhuang and Han subpopulations and between genders (P>0.05), but differed significantly from those in European and African black populations (P<0.01). Three genotypes (CC, CT and TT) were identified in rs10975519C/T with frequencies of 34.3% , 53.0% , and 12.7% , respectively, showing no significant ethnic or gender-specific differences in this population (P>0.05). The genotype frequency of rs10975519C/T in this population differed significantly from those in the European and Japanese populations (P<0.01), but the allele frequencies only showed significant differences from those in the European population (P<0.01). Conclusion rs1891385A/C and rs10975519C/T polymorphisms of IL-33 gene show a race-specific difference.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-27 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To study the distribution of single nucleotide polymorphisms (SNP) of arginine-vasopressin (AVP) gene rs66818855 and rs1078152 in Chinese Guangxi healthy population in comparison with that in different ethnic populations. Methods Polymerase chain reaction-single base extension (PCR-SBE) and DNA sequencing were used to detect the allele and genotype frequencies of AVP gene among 303 Chinese healthy individuals in Guangxi, China, and the results were compared with the reported frequencies in 4 other populations (HapMap-CEU, HapMap-YRI, HapMap-JPT, and HapMap-HCB) from Human Genome Project group (HapMap) data. Results We found significant AVP gene polymorphisms in this Guangxi healthy population. The frequencies of allele and genotype of AVP gene rs66818855 and rs1078152 polymorphisms in this Guangxi population differed significantly from those in HapMap-CEU population (P<0.01), and allele frequencies of AVP gene rs66818855 polymorphism differed significantly from those in HapMap-YRI populations (P<0.05). Conclusion The distribution pattern of AVP gene polymorphisms in this Guangxi population is significantly different from that in other ethnic populations, which might account for the difference in the morbidity of AVP-related disease among different ethnic groups and may have important indications in the study of population genetics and anthropology
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