Association between air pollutant exposure and dyslipidemia in middle-aged and elderly people in western mining area of Hunan province

Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-12-01 Cooperative journals: 《中国全科医学》

奉水东 李君艳 邓蜀湘 陈立谋 曹梦悦 唐艳 唐鹏 刘俊 沈敏学 杨飞

Abstract：

Background Dyslipidemia has become one of the global public health events. However, the relationship between air pollution and dyslipidemia has been rarely reported.� Objective To explore the relationship between air pollutants燼nd hyperlipidemia in the middle-aged and elderly in western mining area of Hunan province. Methods A total of 1965 people over 45 years old in western mining area in Hunan Province, were randomly sampled from a community or village, from 2018 to 2019. The general demographic characteristics, life style, disease history, and the Indicators of Hyperlipidemia [total cholesterol(TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol(HDL-c)] were obtained by using questionnaire, physical examination and laboratory test. The air pollution data of monitoring stations for the first two years of the survey released by Meteorological Department were collected, the air pollution data of the mining area were calculated by inverse distance weighted (IDW) method,and the average daily dose (ADDtotal) of air pollutants is calculated based on the Air Quality Comprehensive Index (AQCI). Logistic regression was used to analyze the relationship between ADDtotal and hyperlipidemia. Results There were 498 cases of hyperlipidemia among the 1,965 people studied,the prevalence rate was 25.3%. The prevalence of abnormal rates of TC, TG, HDL-c and LDL-c were 12.9%,10.6%, 5.4%, 8.8%, respectively. The range of ADDtotal is 0.53~1.83(m3/kg/day). After adjusting for sex, age, smoking, drinking, education, income, body mass index (BMI), hypertension, diabetes and other factors, it was found that Q2, Q3 and Q4 group had a greater risk of abnormal TG [OR (95%CI) values were 2.61(1.38, 4.93),3.42(1.51,7.73) and 5.12(1.77,14.85), respectively], Q4 group had a greater risk of abnormal TC [OR(95%CI)= 2.62(1.02,6.75)]�,燾ompared with Q1 group(the lowest concentration of ADDtotal). Conclusion Air pollutants is associated with abnormal TC and TG.�

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