The Detection Rate of Postpartum Depression in Advanced Maternal Age in China：a Meta-analysis

Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-12-05 Cooperative journals: 《中国全科医学》

LI Long AN Xuemei ZHANG Jie HUANG Linyu ZHANG Xingling

Abstract： Background　With the rapid development of economy and the change of fertility concept in modern population，coupled with the full liberalization of the “two-child” and “three-child” policies，the number of advanced maternal age is increasing year by year. Compared with appropriate maternal age，advanced maternal age is more likely to suffer from depressive symptoms due to personal，family，work，and other reasons. Objective　To systematically evaluate the detection rate of postpartum depression in advanced maternal age（≥ 35 years at delivery） in China to provide relevant evidence for early prevention and intervention. Methods　CNKI，Wanfang，VIP，CBM，PubMed，Cochrane Library，Embase， and Web of Science were searched for articles on the detection rate of postpartum depression in advanced maternal age in China by combining subject terms and free terms from inception to July 2023. The process of literature screening，data extraction and quality assessment were carried out by two researchers independently. Stata 16.0 software was used for data analysis. Results　A total of 21 studies were included，with a total sample size of 5 163. The results of Meta-analysis showed that the overall detection rate of postpartum depression in advanced maternal age in China was 20.0%（95%CI=17.4%-22.6%）. The subgroup analysis revealed that the detection rate of postpartum depression was 19.5%（95%CI=13.8%-25.3%） in women < 40 years old，40.3% （95%CI=11.4%-69.3%） in women ≥ 40 years old，19.7%（95%CI=11.7%-27.7%） in women with high school education level or higher，30.7%（95%CI=19.1%-42.3%） in women with high school education level or lower，21.1%（95%CI=14.4%-27.9%） in primipara，16.2%（95%CI=12.9%-19.6%） in multipara，16.4%（95%CI=12.2%-20.6%） in natural childbirth， 27.8%（95%CI=20.9%-34.8%） in cesarean section，20.7%（95%CI=15.6%-25.8%） in women with male newborn and 27.3%（95%CI=20.5%-34.0%） in women with female newborn； there were 38.7%（95%CI=22.6%-54.8%） women with pregnancy complications，11.7%（95%CI=7.6%-15.8%） women without pregnancy complications，29.5%（95%CI=17.9%- 41.1%） women with adverse pregnancy and childbirth history，27.7%（95%CI=16.6%-38.8%） women without adverse pregnancy and childbirth history，18.0%（95%CI=16.5%-19.4%） published the year before 2020，19.5%（95%CI=18.0%- 21.0%） published the year after 2020，20.4%（95%CI=18.2%-22.6%） in the north and 18.2%（95%CI=17.0%-19.4%） in the south，20.0%（95%CI=18.5%-21.5%） in the Edinburgh Postnatal Depression Scale（EPDS） score ≥ 13 and 16.9% （95%CI=15.2%-18.5%） in the EPDS score ≥ 10. The Egger's test（t=1.76，P=0.095） and the Begg's test（Z=1.48， P=0.147） indicated no significant publication bias. Conclusion　The detection rate of postpartum depression is higher for advanced maternal age in China，including women ≥ 40 years old，with high school education level or lower，primipara， cesarean section，female newborn，pregnancy complications and adverse pregnancy and childbirth history，publish year after 2020，areas of the north，EPDS score ≥ 13，attention should be paid to the psychological status of advanced maternal age，and corresponding prevention and intervention measures should be formulated.

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