Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the effect of thalidomide on the development of bisphosphonate-related osteonecrosis of the jaws (BRONJ). Methods Thirty-six rats were randomly divided into groups A, B and C, and treated with saline, zoledronate and zoledronate plus thalidomide, respectively. Three weeks later, the left maxillary first molars of the rats were extracted. Four and eight weeks after tooth extraction, samples were harvested for evaluation of osteonecrosis of the jaws, microvessel density, and cell apoptosis. Results At both of the time points, no exposed dead bone was observed at the extraction socket areas in the rats except for some small fistulas in groups B and C. Histological examination confirmed the absence of dead bone in group A, whereas small areas of dead bone were observed around the extraction socket in groups B and C. Compared with those in group A, the percentage of empty lacunae and the area of dead bone were significantly increased (P<0.01), whereas bone lacunae density was significantly decreased (P<0.01) in groups B and C at both time points. Microvessel density in groups B and C were also significantly decreased (P<0.01) by 25.87% and 55.27% at week 4, and by 45.62% and 72.84% at week 8, respectively; the apoptotic cells in groups B and C increased by 54.80% and 87.89% at week 4 (P<0.01), and by 208.08% and 250.58% at week 8 (P<0.01), respectively. Conclusion Thalidomide can aggravate zoledronate-induced early-stage BRONJ, and their osteonecrosis-inducing effect of the jaw may be attributed, at least partly, to the inhibition of angiogenesis.
Subjects: Dynamic and Electric Engineering >> Engineering Thermophysics submitted time 2017-11-07 Cooperative journals: 《工程热物理学报》
Abstract：氧气在质子交换膜(PEM)燃料电池阴极的还原反应特性对电池性能有重要影响。本文通过建立电催化剂Pt表面的氧吸附模型，及氢与氧在Pt表面进行的氧化还原反应模型，运用分子动力学方法模拟研究了氢原子与氧在Pt表面的反应机理，分析了温度对氧气还原反应特性的影响。研究发现，氢原子和氧原子在Pt表面初次吸附是整个氧气还原反应的控制步骤;随着温度升高，氧气还原反应的速度加快，但温度不影响氧气还原反应各个步骤中的产物结构。研究结果对加强理解PEM燃料电池反应机理，推动燃料电池的应用具有重要意义。
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