Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-06-09 Cooperative journals: 《中国全科医学》
Abstract： Mental illness usually involves a range of cognitive，behavioral，and affective symptoms associated with impaired occupational or social functioning. Duration of untreated psychosis（DUP） is considered as an important predictor and independent risk factor for the prognosis of patients with mental disorders，a longer DUP is associated with poor prognosis. Meanwhile，early intervention measures to shorten DUP have gradually attracted increasing attention from both domestic and international researchers. In this paper，the related studies on DUP were reviewed and analyzed，the concept，measurement tools，neurobiological mechanisms of DUP，the relationship between DUP and prognosis，and early intervention measures to shorten DUP were described，in order to provide ideas and reference for developing clinical intervention strategies for DUP.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-03 Cooperative journals: 《中国全科医学》
Abstract：
Objective To explore the effect of time-point matching intervention (DPM) program on disability, negative symptoms, insight, self-esteem level and family function in patients with schizophrenia disability. Methods The patients at P1 (70 cases), P2 (70 cases) and P3 (70 cases) were randomly divided into intervention group (35 cases) and control group (35 cases) by SPSS. The control group was given routine care, and the Intervention group was given the time point matching intervention. The duration of the intervention was 8 weeks, once a week. They were assessed using WHO-DAS II, PANSS-N, ITAQ, SES, and APGAR at baseline, after intervention, 3 months and 6 months after intervention. The health outcomes were compared by repeated measures analysis of variance. Results There was no significant difference in baseline data between the two groups at P1, P2 and P3 (P > 0.05).The results of repeated measures analysis of variance showed that after DPM intervention, there were time, group main effect and interaction effect in the degree of disability, negative symptoms, insight, and self-esteem of patients at P1.There were time main effects and interaction effects in family function, and the improvement of the above indicators in the intervention group was better than that in the control group at after intervention, 3 months and 6 months after intervention, and the difference was statistically significant (P < 0.05).There were time, group main effect and interaction effect in disability degree, insight, self-esteem, and family function of patients at P2. Except that there was no significant difference in the degree of disability and self-esteem at 3 months after intervention between the two groups (P > 0.05), other indicators were significantly different between the two groups after intervention, 3 months and 6 months after intervention (P < 0.05). There were time, group main effects and interaction effects on the degree of disability and insight of patients at P3. The improvement of the above indicators in the intervention group was better than that in the control group after intervention, 3 months after intervention and 6 months after intervention, and the difference had statistical significance (P < 0.05). Conclusion The DPM intervention program is effective in improving the disability degree, negative symptoms, insight, self-esteem and family function.
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