Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-03 Cooperative journals: 《中国全科医学》
Abstract：
Background The chronic kidney disease (CKD) seriously harms the health and the life span of the elderly. Hypertension is closely related to CKD. However, there are few cohort studies focusing on the blood pressure levels and CKD in the older adults. Objective To investigate the relationship between blood pressure and the risk of chronic kidney disease in the elderly aged 65 years and older. Methods Based on the "Chinese Longitudinal Healthy Longevity Survey (CLHLS)", 989 elderly people who underwent physical examination and biomedical indicator tests in 2012 were selected as subjects. Biomedical indicators including age, sex, height, weight, blood pressure, blood lipid, blood glucose and urine test were collected at baseline. The follow-up monitoring was conducted in 2014. Cox proportional hazard model was used to analyze the association between different blood pressure levels and the risk of CKD. Results 989 subjects, with an average age of 80.2±12.0 years, were included in the study. A total of 183 cases of CKD were diagnosed during an average follow-up time of 2.07 years. The cumulative incidence of CKD during the follow-up period was 18.5% (95%CI: 16.1%-21.1%), and the incidence density was 89.4/1000 person-years. Compared with normal blood pressure, older adults with hypertension, after adjusting for multiple factors, had a higher risk of CKD [HR (95%CI) 2.28 (1.13-4.60)]. The risk of CKD in older adults with baseline SBP ≥ 140mmHg was 1.83 times higher than that in older adults with SBP<120mmHg (95%CI: 1.02-3.29). The risk of CKD with baseline DBP ≥ 90mmHg was 1.55 times higher than those with DBP<80mmHg (95%CI: 1.02-2.35). Conclusion Elevated blood pressure is an independent risk factor for chronic kidney disease in the elderly. To increase screening and prevention of CKD is particularly important, especially for those with elevated systolic blood pressure.
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