Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-12-06 Cooperative journals: 《中国全科医学》
Abstract： Background As a neurodegenerative disease，Alzheimer's disease（AD） has a high incidence rate and rapid development，which seriously affects the quality of life of patients. In recent years，research on music therapy intervention in AD has gradually increased，lacking effective systematic evaluation and analysis. Objective A meta-analysis was conducted on the intervention effects of music in the treatment of cognition，emotion，living ability and sleep disorders in AD patients. Methods A randomized controlled trial was conducted on the intervention effect of music therapy methods on Alzheimer's patients in the Chinese Journal Full Text Database（CNKI），Wanfang Database（Wanfang），VIP Database（VIP），Medline，Elsevier ScienceDirect，PubMed，and Embase by computer search. The search time was from the establishment of each database until February 2023，and the data was analyzed using Review Manager 5.4 software. Results The study included 15 RCT studies with a total of 1 077 patients. The results of meta-analysis showed：The effects of music therapy on cognitive function（MD=4.35，95%CI=1.64 to 7.05，Z=3.15，P=0.002），negative emotion（SMD=-0.71，95%CI=-1.26 to -0.15，Z=2.51，P=0.01），life ability（SMD=-0.91，95%CI=-1.55 to -0.27，Z=2.77，P=0.006） The effect of intervention was better than that of control group. There was no significant difference in sleep disorder intervention between the two groups （MD=-1.04，95%CI=-3.10 to 1.02，Z=0.99，P=0.32）. Subgroup analysis showed that The treatment period was <12 weeks （P=0.01），the treatment duration was <45min/ time（P=0.02），the treatment frequency was ≥ 3 times/week（P<0.001），the implementation method was individual（P<0.001），the implementation method was individual + group（P=0.002），and the intervention measure was receiving music therapy（P<0.001） The effect of intervention on cognitive function in the group was better than that in the control group. Treatment period ≥ 12 weeks（P=0.004），treatment frequency <3 times/week（P=0.01），implementation method of individual + group（P=0.02），intervention measure of receiving music therapy（P=0.002），intervention measure of active music therapy（P=0.002），the intervention effect of music intervention group on negative emotions was better than the control group. Conclusion Music therapy can improve the cognitive function，mental state，and daily self activity of Alzheimer's patients. However，due to the low quality of case studies included，more large-scale and high#2;quality evidence-based studies are still needed to verify.
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