Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-10-12
Xia，qingqing
Chen，Jingyan
Sun，qin
Liu，yaoxia
Ren，min
Liu，yang
Cao，xiaohong
Tang，xialian
Li，yongling
zhang， min
Abstract： Objective：This study compared the effects of dapagliflozin and linagliptin on weight and body composition in elderly T2DM patients who had already been treated with metformin for poor blood sugar control.
Methods：Totally 106 elderly patients with type 2 diabetes who had received metformin treatment and had HbA1c levels of more than 7.0% were randomly divided into dapagliflozin and linagliptin groups. Bioimpedance analysis was used to assess body composition before and after the study.
Results：The average body weight change from baseline to 24 weeks in the dapagliflozin group was -3.78 kg . Dapagliflozin also significantly reduced muscle massand total body protein. Compared with linagliptin, dapagliflozin resulted in a greater decrease in body fat mass from baseline to week 24, the statistical difference was significant.
Conclusion：Dapagliflozin significantly reduces body weight, including body fat and lean weight, and should be used with caution in elderly frail patients.
Peer Review Status:
Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-10-10
Abstract： Abstract：
Objective To evaluate the effect of dawn phenomenon (DP) and glucose variability on cognitive function of elderly patients with type 2 diabetes mellitus, and to explore the correlation and risk factors between dawn phenomenon and cognitive dysfunction.
Methods The patients were divided into DP group (18 cases) by Flash Glucose Monitoring data, and the NDP group (18 cases) was matched according to age, gender, HbA1c and education level. The glucose level, glucose variability and cognitive function of the two groups were compared by paired t test; The correlation between cognitive dysfunction and other indicators were analyzed by person correlation analysis and stepwise multiple linear regression.
Results There were statistically significant differences in TIR, TAR, SD, MBG, CIMT and MoCA scores between two groups (P < 0.05). Correlation analysis showed that cognitive impairment was negatively correlated with age, tar, SD, MBG, CIMT (r=0.509, -0.338, -0.341, -0.341*, -0.345*, p<0.05), Stepwise multiple linear regression analysis suggested that age and SD were the risk factors of cognitive dysfunction. Conclusion Elderly type 2 diabetic patients with dawn phenomenon have higher blood glucose level, increased blood glucose fluctuation, and increased degree of atherosclerosis, which are more likely to lead to cognitive impairment.
Peer Review Status:Awaiting Review
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