分类: 生物学 >> 生物物理学 >> 肿瘤学 提交时间: 2016-05-11
摘要: Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresistance, colony-formation, cytokine secretion and invasiveness in vitro. Most importantly, granzyme M facilitated tumor growth and metastasis in vivo. Granzyme M induced the epithelial-mesenchymal transition (EMT) in cancer cells associated with STAT3 activation. Our study revealed the role of granzyme M expressed by tumor in chemoresistance, invasion, metastasis and EMT.
分类: 物理学 >> 基本粒子与场物理学 提交时间: 2016-05-09
摘要: The multi-sector SUSY breaking predicts pseudo-goldstino which can couple to the visible sector more strongly than the ordinary gravitino and thus induce the decays of the lightest neutralino and chargino (collectively called electroweakinos) inside the detector. In this note we study the electroweakino pair productions via VBF processes followed by decays to pseudo-goldstino at the LHC. Our Monte Carlo simulations show that at the 14TeV LHC with 3000 fb(-1) luminosity the dominant production channel pp ->chi(+/-)(1)chi(0)(1)jj can have a statistical significance above 2 sigma while other production channels are not accessible.