Subjects: Biology >> Biophysics Subjects: Materials Science >> Biomaterials Subjects: Chemistry >> Chemical Biology Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2023-02-09
Abstract：
Nanotechnology has provided considerable promise for the biological and medical fields, especially in the subjects of biological and medical imaging for the last two decades. Here, we outline different nanoparticles to contribute to biological and medical imaging disciplines. These concerned nanoparticles are soft nanoparticles, which are based on biomacromolecule/polymer or organic molecule components, hard nanoparticles that are derived from various inorganic components and hard-soft nanoparticles that are based on both inorganic components and biomacromolecule/polymer or organic molecule ones. We also discuss the imaging modalities in biology and medicine that various nanoparticles became involved in are: (1) optical imaging (OI), (2) computed tomography (CT), (3) magnetic resonance imaging (MRI), (4) ultrasonography (USG), (5) positron emission tomography (PET). We will also describe various nanoparticles to serve for one/some of those five modalities in biology and medicine imaging in this review paper.
Peer Review Status:
Awaiting Review
Subjects: Materials Science >> Nanoscience and Nanotechnology submitted time 2022-10-04
Abstract： Nanotechnology has provided considerable promise for the biological and medical fields, especially in the subjects of biological and medical imaging for the last two decades. Here, we outline different nanoparticles to contribute to biological and medical imaging disciplines. These concerned nanoparticles are soft nanoparticles, which are based on biomacromolecule/polymer or organic molecule components, hard nanoparticles that are derived from various inorganic components and hard-soft nanoparticles that are based on both inorganic components and biomacromolecule/polymer or organic molecule ones. We also discuss the imaging modalities in biology and medicine that various nanoparticles became involved in are: (1) optical imaging (OI), (2) computed tomography (CT), (3) magnetic resonance imaging (MRI), (4) ultrasonography (USG), (5) positron emission tomography (PET). We will also describe various nanoparticles to serve for one/some of those five modalities in biology and medicine imaging in this review paper.
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-06-15 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate whether pigment epithelium-derived factor (PEDF) inhibits invasion and metastasis of breast cancer through regulation of epithelial-mesenchymal transition. Methods The expressions of PEDF, vimentin, and E-cadherin were detected in 119 breast cancer tissues using immunohistochemistry. SK-BR-3 breast cancer cell models of PEDF knockdown and PEDF overexpression were established by transfecting the cells with a PEDF-siRNA vector and a lentivirus-PEDF vector, respectively. Western blotting was used to detect the changes in the expressions of PEDF, vimentin, and E-cadherin in the cells, and the cell invasion and migration ability was assessed using scratch wound healing assay and transwell migration assay. Results PEDF positivity rate was significantly lowered in breast cancer tissues compared with the adjacent tissues. PEDF was positively correlated with the tumor size and the expression level of E-cadherin (r=0.473, P<0.001), but was negatively correlated with vimentin expression (r=-0.412, P<0.001). Transwell invasion experiment showed that PEDF interference enhanced the cell invasion and metastasis, while PEDF overexpression inhibited the invasion and migration of SKBR-3 cells. Western blotting showed that PEDF knockdown significantly decreased the expression of E-cadherin (P<0.05) and increased vimentin expression in the cells (P<0.05). Conclusion PEDF is closely related with the metastasis of breast cancer cells through regulation of epithelial-mesenchymal transition.
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