Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2023-08-17
Abstract： Objective To analyze the disease burden and changes in risk factors of common malignant tumors in the female reproductive system in China from 1990 to 2019. Method Using the 2019 global disease burden database data, describe the changes in indicators such as incidence, death, and disability adjusted life years (DALY), early death lost life years (YLL), and disability lost life years (YLD) of cervical cancer, uterine cancer, and ovarian cancer in China from 1990 to 2019. Estimate the levels of different risk factors using the population attributable risk percentage. Results From 1990 to 2019, the incidence rate and mortality of cervical cancer, uterine cancer and ovarian cancer in China showed an upward trend. The incidence rate of ovarian cancer increased by 0.78%, the highest increase. In 2019, the age of high incidence of cervical cancer and uterine cancer was 55 to 59 years old, while the age of high incidence of ovarian cancer was 70 to 74 years old. The DALY, YLL, and YLD of cervical cancer, uterine cancer, and ovarian cancer increased to varying degrees in different age groups. Among the risk factors leading to DALY and DALY rates, cervical cancer is characterized by smoking (145300 person years/20.83%) and risky sexual behavior (1622200 person years/23.257%), uterine cancer is characterized by high body mass index (BMI) (90800 person years/13.02%), ovarian cancer is characterized by high BMI (16700 person years/2.39%), high blood sugar (44600 person years/6.40%), and occupational exposure to asbestos (7900 person years/1.13%). Compared to 1990, the largest increase in China's DALY rate in 2019 was attributed to ovarian cancer, which was attributed to high BMI, high blood sugar, and occupational exposure to asbestos, with increases of 482.93%, 253.59%, and 162.79%, respectively, with growth rates much higher than global levels. Conclusion From 1990 to 2019, the disease burden of common malignant tumors in the reproductive system of Chinese women showed an overall upward trend. It is necessary to prioritize the prevention and control of menopausal and postmenopausal women, increase publicity and education for the three types of cancer, advocate healthy lifestyles, actively carry out cancer screening, and increase people's willingness to receive vaccines, in order to reduce the disease burden of cervical cancer, uterine cancer, and ovarian cancer in Chinese women.
Peer Review Status:
Awaiting Review
Subjects: Biology >> Zoology submitted time 2018-12-24 Cooperative journals: 《动物营养学报》
Abstract：岩藻糖是肠道上皮细胞黏蛋白糖基化的重要糖基，可以作为肠道微生物的能量物质，参与肠道微生物的黏附、定植以及免疫调节，对于促进肠道微生物稳态，维持肠道健康有重要作用。本文主要对岩藻糖基化过程，岩藻糖在肠道中的积极调控作用以及肠道微生物、免疫细胞对岩藻糖表达的诱导进行综述，以期为维持肠道微生物稳态和肠道健康提供新的参考
Subjects: Biology >> Zoology submitted time 2017-10-23 Cooperative journals: 《动物营养学报》
Abstract：随着我国经济的发展与人民生活水平的提高，具有丰富营养价值的乳及乳制品逐渐成为人民日常生活的必需消费品。与此同时，人们对乳及乳制品的期待不再局限于量的提高，而是对其质量和安全提出了更高的要求。由于2011年发生的牛奶中黄曲霉毒素M1(AFM1)含量超标事件，以及相比于成人，婴幼儿更易受到牛奶中AFM1的损害，人们更加开始重视乳及乳制品中存在的AFM1污染问题。本文在国内外已有文献报道基础上，对乳及乳制品中AFM1的来源与生物学性质、污染与限量标准、检测与防控技术进行综述。
Subjects: Biology >> Zoology submitted time 2017-10-23 Cooperative journals: 《动物营养学报》
Abstract：近年来，牛奶质量安全问题频发，已严重威胁到公共健康。因此，牛奶质量安全成为国际关注的重点。当牛奶中残留兽药时，会对消费者造成不良的影响。本文从牛奶中兽药检测技术的原理和优缺点出发，对牛奶中兽药残留的检测技术进行了较全面的综述，并对牛奶中兽药残留检测技术在未来的发展方向作了展望。
Subjects: Biology >> Zoology submitted time 2017-10-10 Cooperative journals: 《动物营养学报》
Abstract：本试验旨在研究不同浓度的组氨酸对体外培养奶牛乳腺上皮细胞β-酪蛋白及酪氨酸激酶2（JAK2）-信号转导与转录激活子5（STAT5）/哺乳动物雷帕霉素靶蛋白（mTOR）信号通路相关磷酸化蛋白表达的影响。将原代奶牛乳腺上皮细胞进行体外培养，分为对照组和7个试验组，采用无必需氨基酸的培养基，对照组不添加组氨酸，试验组是在对照组基础上分别添加0.15、0.60、1.20、2.40、4.80、9.60、19.20 mmol/L的组氨酸。采用噻唑蓝比色法检测原代奶牛乳腺上皮细胞12 h增殖；运用蛋白质免疫印迹检测β-酪蛋白和7个信号通路相关磷酸化蛋白表达。结果表明：1）当组氨酸浓度为0.15~9.60 mmol/L时，与对照组相比，奶牛乳腺上皮细胞数量均增加。2）β-酪蛋白表达量随组氨酸浓度的增加出现先升高后降低的趋势，但试验组均极显著高于对照组（P<0.01）。3）与对照组相比，组氨酸的添加可极显著促进各信号通路相关磷酸化蛋白的表达（P<0.01）；试验组中，随着组氨酸浓度的升高，磷酸化哺乳动物雷帕霉素靶蛋白[P-mTOR（Ser2481）]和磷酸化真核细胞翻译延伸因子2[P-eEF2(Thr56）]蛋白的表达量下降，而磷酸化核糖体S6蛋白激酶1[P-S6K1(Thr389)]的蛋白表达增加；当组氨酸浓度为2.40 mmol/L时，磷酸化酪氨酸激酶2[P-JAK2(Tyr1007/1008）]、磷酸化真核细胞始动因子4E结合蛋白1[P-4EBP1（Thr37）]和磷酸化真核细胞起始因子2α[P-eIF2α(Ser51）]蛋白的表达量最高，磷酸化信号转导与转录激活子5[P-STAT5(Tyr694)]、磷酸化mTOR调控蛋白[P-raptor(Ser863)]和mTOR复合物1中的绑定蛋白（GβL）蛋白在组氨酸浓度为9.60 mmol/L时表达量最高。综合可知，组氨酸的添加可通过促进JAK2-STAT5信号通路中P-JAK2(Tyr1007/1008)和P-STAT5(Tyr694)蛋白的表达来进而调控β-酪蛋白表达。最适浓度（0.15~9.60 mmol/L）范围内的组氨酸还可通过mTORC1的P-raptor(Ser863)蛋白作用于下游靶点P-4EBP1(Thr37)来促进β-酪蛋白表达，最终调控乳蛋白合成。
Subjects: Biology >> Zoology submitted time 2017-10-10 Cooperative journals: 《动物营养学报》
Abstract：热应激不仅影响奶牛健康，而且易导致奶牛“热应激乳蛋白降低征”的发生，从而影响牛奶营养品质。本文综述了近些年来热应激影响牛奶中乳蛋白含量及酪蛋白和乳清蛋白组分的研究进展，探讨了热应激诱导的“热应激乳蛋白降低征”发生机理，以期为缓解奶牛热应激和提高牛奶品质提供参考。
Subjects: Biology >> Zoology submitted time 2017-10-10 Cooperative journals: 《动物营养学报》
Abstract：作为维持哺乳动物生命活动重要的“生物工厂”，乳腺利用从流经血液中摄取的氨基酸等营养物质为底物合成乳蛋白。研究证实，氨基酸还可作为一种信号因子，通过乳腺内多种信号级联传导通路，调控乳蛋白基因的转录及翻译过程，从而影响乳腺中乳蛋白的合成。酪氨酸蛋白激酶–信号转导子和转录激活子（JAK-STAT）信号通路和哺乳动物雷帕霉素靶蛋白（mTOR）信号通路是乳蛋白基因转录和翻译过程中的主要调控路径。本文综述了乳腺JAK-STAT和mTOR信号通路的分子机制及氨基酸通过这些通路调控乳蛋白合成的研究进展，旨在进一步阐明氨基酸调控乳蛋白合成的作用机理。
Subjects: Biology >> Zoology submitted time 2017-10-10 Cooperative journals: 《动物营养学报》
Abstract：霉菌毒素是一类广泛存在于饲料原料和人类食品中，对动物和人类健康造成严重威胁的危害因子。作为机体抵御外来污染物的第1道屏障，肠道黏膜屏障主要由相互联系的机械屏障、化学屏障、免疫屏障和生物屏障构成。本文在国内外已有的研究基础上，对霉菌毒素对肠道黏膜屏障功能的影响及其作用机制进行综述。
Hits
Hits
Downloads
Comment