Subjects: Materials Science >> Electronic, Optical and Magnetic Materials Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2022-05-08
Abstract:
In this work, the near ultraviolet femtosecond laser pulse is used to fabricate waveguides and Bragg gratings in poly methyl pentene (PMP). It is observed that the polymer exhibits sensitivity for the light polarization. In low NA processing, by supercontinuum spectrum estimation, the process window of peak power ranges from 2.2MW to 9.2MW. It is inferred that the nonlinear refractive index is n2387=2×10-16cm2W-1 and the third-order susceptibility χ(3) is calculated to be 1.1×10-14esu. Filamenting-process length varies from 300μm to 1500μm along with the increase of pulse energy and the length is a power function of peak energy with power index of ~ 0.53. The maximum of refractive index change is 0.01 which is inferred from the first grating diffraction efficiency, an order higher than the previous figures. These results show that the pulse peak intensity is critical to induce nonlinear absorption in terms of the two-photon absorption. The experimental data provides the latest data for scientific researchers and optical engineers.
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-21 Cooperative journals: 《南方医科大学学报》
Abstract: Objective To investigate the changes of autophagy in ischemic myocardium of rats treated with fasudil for inhibiting Rho kinase. Methods The hearts isolated from male Sprague-Dawley rats were subjected to 30 min of occlusion of the left anterior descending artery followed by 120 min of reperfusion with or without treatment with fasudil or fasudil+Wort. The left ventricular hemodynamics were continuously recorded, and the coronary effluent was collected during the reperfusion to determine lactate dehydrogenase (LDH) levels. The mRNA expressions of autophagy-related genes Atg5 and Beclin1 and apoptosis-related genes bax and bcl-2 were detected by RT-PCR, and the protein expression of caspase-3 was detected by Western blotting. Results Compared with I/R group, fasudil significantly improved the left ventricular developed pressure, maximal rise/fall rate of left ventricular pressure and rate pressure product, reduced LDH release during reperfusion, increased Atg5 and Beclin1 mRNA expression and the ratio of Bcl-2/Bax, and lowered caspase 3 protein expression. The autophagy inhibitor Wort significantly attenuated the effect of fasudil in the rat hearts. Conclusion Fasudil treatment for inhibiting Rho kinase promoted autophagy in ex vivo rat heart to protect against myocardial ischima-reperfusion injury possibly by reducing apoptosis of the cardiac myocytes.