Subjects: Biology >> Botany >> Applied botany submitted time 2021-11-04 Cooperative journals: 《广西植物》
Abstract： To study the anti-inflammatory of chemical constituents from the rhizome of ethnomedicine Rosa roxbunghii. The chemical constituents of fresh R. roxbunghii rhizome were studied by phytochemical separation and purification technology, and their structures were identified through physicochemical properties and spectral data. The inflammatory model of RAW264.7 induced by lipopolysaccharide (LPS) in vitro was established. The cell viability was detected by MTT assay, the release of inflammatory factor NO in the cell culture medium was detected by Griess method and the anti-inflammatory activity of each compound was evaluated through the kit. The results were as follows: (1)Fifteen compounds were isolated and identified as kaji-ichigoside F1(1), rosamultin(2), euscaphicacid(3),β-D-glucopyranosyl-(2a→1b)-2a-O-β-L-arabinopyranosyl-(2b→1c)-2b-O-β-L-arabinopyranosyl-(2c→1d)-2c-O-β-L-arabinopyranosyl-(2d→1e)-2d-O-β-L-arabinopyranosyl-(2e→1f)-2e-O-β-L-arabinopyranoside(4),catechin(5), 3-O-methylellagic acid-4´-O-β-D-xylopyranoside(6), 3-O-methylellagic acid-4´-O-α-L- rhamnopyranoside (7), tormentic acid (8), betulinic acid (9), spinosic acid (10) , arjunic acid (11), β-Sitosterol (12), β-Daucosterol (13), α-tocopherol (14) and n-hexacosane (15). Compounds 4, 6 and 7 were isolated from R. roxbunghii for the first time. (2)The results of in vitro bioactivity showed that compounds 1-7 significantly inhibited LPS induced NO release from RAW264.7 in a dose-dependent manner; The IC50 were 25.07, 24.56, 17.65, 9.87, 16.67, 40.83 and 34.98 μmol·L-1, respectively (dexamethasone as positive control 22.46 μmol·L-1 ). Anti-inflammatory activity of compounds 1-7 were showed better, among which compounds 3, 4 and 5 were slightly better than dexamethasone. The results indicated that triterpenoids, ellagic acids, flavonoids and oligosaccharides from R. roxbunghii were the main effective components and verified its anti-inflammatory effect in folk application.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To evaluate the MSCT value in diagnosing the fracture of femoral neck. Methods The MSCT and clinicalfeatures of 102 cases with fracture of femoral neck were analyzed retrospectively. Results Sixteen cases were fracture ofsubcapital type, 24 cases were fracture of cervical type, 62 cases were fracture of basilar type. 18 cases were fracture ofsubcapital Garden Ⅰ, 59 cases were fracture of subcapital Garden Ⅱ, 19 cases were fracture of subcapital Garden Ⅲ, 6 caseswere fracture of subcapital Garden IV. 3 cases of secondary ischemic necrosis. Conclusion Transcervical fracture can bediagnosed by MSCT comprehensively and accurately, which has important significance for the treatment and prognosis of thepatients.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： Environmental and health problems caused by chemical pollution, especially high-risk chemical pollution, have become an important factor affecting the public health. How to ensure that chemicals bring well-being to human society, while ensuring that they minimize their harm to the environment and human health, is a problem that needs to be solved urgently in the field of chemistry, especially environmental chemistry. This article summarizes the latest research progress in the risk identification, risk prevention, alternative research and development and evaluation of perfluorinated compounds and other substances, and systematically explores how to use green chemistry, combined with the risk management and control, to decrease the risk of the high-risk chemicals during their entire life cycle. The article also discusses the research progress, development direction, and future development of high-risk chemicals throughout the life cycle.
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