分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 分类: 物理学 >> 凝聚态:电子结构、电、磁和光学性质 分类: 物理学 >> 电磁学、光学、声学、传热、经典力学和流体动力学 分类: 物理学 >> 交叉学科物理及相关领域的科学与技术 提交时间: 2022-03-24
摘要: 非厄米的引入扩展了传统厄米量子系统中的概念并诱导出许多新奇的物理现象, 比如非厄米系统所独有的非厄米趋肤效应, 这使得对非厄米量子模型的模拟成为大家关注的热点. 相比于量子平台, 经典系统具有成本低廉、技术成熟、室温条件等优势, 而其中的经典电路系统则更加灵活, 原则上可以模拟任意维度、任意格点间跃迁、任意边界条件下的量子紧束缚模型, 已经成为模拟量子物态的有力平台.本文利用经典电路通过 SPICE 成功模拟了一个重要的非厄米量子模型 非互易 Aubry-Andr\'e 模型 的稳态性质, 此模型同时具有非互易的格点跃迁和准周期的格点在位势. 以此为例, 详细介绍了如何建立经典电路的拉普拉辛形式与量子紧束缚模型哈密顿矩阵在不同边界条件下的映射, 尤其是如何利用电流型负阻抗变换器构建模型的非互易性. 然后, 根据电路的格林函数, 通过 AC 电流驱动并测量电压响应的方式, 用 SPICE 模拟了周期边界条件下的复能谱和相应的能谱缠绕数, 以及开边界条件下的趋肤与局域模式的竞争.其中, 为了使电路的响应不发散, 本文还解析地给出辅助元件的设置原则.结果显示, SPICE 模拟与理论计算很好地吻合, 为进一步的实验实现提供了详细的指导. 由于本文电路设计与测量方案的普适性, 原则上可以直接应用于其他非厄米量子模型的电路模拟.
分类: 物理学 >> 核物理学 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: The Monte Carlo method can be widely applied to particle transport through numerous simulated data processing operations. However, this process consumes much time. Traditional parallel computing based on multi-CPU or multi-core CPU can effectively address this issue, but it is limited by inadequate computer hardware. Nonetheless, the current programmability and parallel processing capability of digital graphics processing units (GPUs) can sustain general computing applications such as Monte Carlo program simulation. This paper presents a method that facilitates the parallel computation of the Monte Carlo procedure through GPUs. Its feasibility is verified through a sample of simplified photon transport program, the results indicate that execution time can be shortened by approximately 90 times. Based on the general Monte Carlo program Geant4, the photon and electronic coupled transport module was examined, analyzed, and rewritten using the GPU programming language OpenCL to generate a Geant4 parallel tool [base on GPU parallel computing tool (BOGPT)]. The simulation results of the standard examples demonstrated that the outcomes of the BOGPT program are similar to those of Geant4 and the simulation time can be reduced by approximately three times. Finally, the GPU programming-based parallel computing method for Monte Carlo applications is accelerated and implementation prospects are broadened following further optimization.
分类: 物理学 >> 核物理学 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: In the process of neutron spectrum measurement using the multi-sphere neutron spectrometer, energy response functions and detector readings should be applied to neutron spectrum unfolding. Mathematically, there can be multiple solutions to this problem, but only one actual neutron spectrum exists. Compared with common numerical spectrum unfolding methods, genetic algorithms have the characteristics of global optimization and probabilistic search. Therefore, they are chosen to be the spectrum unfolding algorithms for the multi-sphere neutron spectrometer (MNS IL100) developed by Tsinghua University. Firstly, the detector and different size polyethylene spheres of MNS IL100 were modeled to calculate the energy response functions by applying Monte Carlo simulation. Then based on the physical and mathematical properties of the spectrum unfolding problem by using genetic algorithms, effective search space and proper fitness function were determined to improve the efficiency of search and iteration. The elitism replacement scheme was used to ensure convergence and the pseudo-parallel strategy was used to inhibit premature convergence. According to the algorithms mentioned above, a spectrum unfolding code was developed and tested with several typical neutron spectra. At last, MNS IL100 and the spectrum unfolding code were used in actual experiment of 252Cf neutron source spectrum measurement. The experimental result is in good agreement with the 252Cf standard neutron spectrum, verifying the effectiveness and practicality of using genetic algorithms to unfold the neutron spectrum with combination of several processing strategies.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-12
摘要: The (3R)-hydroxyacyl-ACP dehydratase HadAB, involved in the biosynthetic pathway for mycolic acid (MA) of Mycobacterium tuberculosis, catalyzes the third step in the fatty acid (FA) elongation cycle, which is an ideal and actual target for anti-tubercular agent. Though HadAB is predicted to be a member of the hotdog superfamily, it shares no sequence identity with typical hotdog fold isoenzyme FabZ. To characterize the significance of HadAB from the perspective of structural biology, large amount of pure HadAB complex is required for biochemical characterization and crystallization. Here, we used a unique expression and purification method. HadA and HadB were cloned separately and co-expressed in Escherichia coli. After GST affinity chromatography, two steps of anion exchange chromatography and gel filtration, the purity of the protein as estimated by SDS-PAGE was >95%. Using hanging-drop vapor-diffusion method, crystals were obtained and diffracted X-rays to 1.75 angstrom resolution. The crystal belongs to space group P4(1)2(1)2, with unit-cell parameters a = b = 82.0 angstrom, c = 139.8 angstrom, alpha = beta = gamma = 90.0 degrees. (C) 2015 The Authors. Published by Elsevier Inc.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-12
摘要: Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P1, with unit-cell parameters a = 54.97, b = 69.60, c = 70.32 angstrom, alpha = 103.71, beta = 111.06, gamma = 105.83 degrees. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 angstrom with an R-cryst and R-free of 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix-turn-helix domain connected to an alpha-helical dimerization domain.
分类: 生物学 >> 生物物理学 >> 生物物理、生物化学与分子生物学 提交时间: 2016-05-12
摘要: MutM (Formamidopyrimidine-DNA glycosylase, Fpg), a bifunctional base excision repair enzyme (DNA glycosylase/AP lyase), is involved in the repair of many kinds of DNA damage, including the formation of 8-oxoguanine, 5-formyluracil, and C/C mismatches, through recognizing DNA damage and removing damaged bases. The mechanisms of MutM involvement, however, with the exception of 8-oxoG, are poorly understood. Here, we identified proteins which interact with MutM in Mycobacterium smegmatis using methods of tandem affinity purification and mass spectrometry and used Far-western and GST pull-down analysis to validate the interactions between MutM and DEAD-box rna helicase, RpsC, and UvrA. Results demonstrated that tandem affinity purification is a suitable method for identifying MutM interacting proteins and provided insights into the mechanism by which MutM is involved in DNA damage repair.
分类: 核科学技术 >> 放射性计量学 提交时间: 2024-04-26
摘要: The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter method. This study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method. A dead-time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system, and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction curve. The uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of uncertainty. The MCM provided clear definitions for each input quantity and its uncertainty distribution, and the simulation training was realized with a complete and complex mathematical model. The results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed an uncertainty consistency En < 0.070 for the comparison of each source, and the uncertainty results of the GUM were all lower than those of the MCM. However, the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.
分类: 核科学技术 >> 粒子加速器 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: Induced radioactivity is one of the essential problems in the radiation protection field of proton accelerators. Research on the induced radioactivity of low-energy proton accelerators is highly limited. Given such context, this study investigates the cross section of 63Cu (p, n) 63Zn and 65Cu (p, n) 65Zn in Cu targets at 11 MeV proton accelerators through an activation experiment. The uncertainties of the results are analyzed in detail. Results show that the cross section of the reaction of 65Cu (p, n) 65Zn in the experiment is only 1.36% lower than that of the FLUKA simulation, whereas the reaction of 63Cu (p, n) 63Zn in the experiment is 25.4% higher than that of the FLUKA simulation. Given that the benchmark for the FLUKA code of low-energy proton accelerators is very limited, this study provides a reference in this field.
分类: 光学 >> 量子光学 提交时间: 2023-02-19
摘要: The effects of gain and loss on the band structures of a bulk topological dielectric photonic crystal (PC) with $C_{6v}$ symmetry and the PC-air-PC interface are studied based on first-principle calculation. To illustrate the importance of parity-time (PT) symmetry, three systems are considered, namely the PT-symmetric, PT-asymmetric, and lossy systems. We find that the system with gain and loss distributed in a PT symmetric manner exhibits a phase transition from a PT exact phase to a PT broken phase as the strength of the gain and loss increases, while for the PT-asymmetric and lossy systems, no such phase transition occurs. Furthermore, based on the Wilson loop calculation, the topology of the PT-symmetric system in the PT exact phase is demonstrated to keep unchanged as the Hermitian system. At last, different kinds of edge states in Hermitian systems under the influences of gain and loss are studied and we find that while the eigenfrequencies of nontrivial edge states become complex conjugate pairs, they keep real for the trivial defect states.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-12
摘要: S-layer proteins create a cell-surface layer architecture in both bacteria and archaea. Because S-layer proteins self-assemble into a native-like S-layer crystalline structure in vitro, they are attractive building blocks in nanotechnology. Here, the potential use of the S-layer protein EA1 from Bacillus anthracis in constructing a functional nanostructure is investigated, and apply this nanostructure in a proof-of-principle study for serological diagnosis of anthrax. EA1 is genetically fused with methyl parathion hydrolase (MPH), to degrade methyl parathion and provide a label for signal amplifi cation. EA1 not only serves as a nanocarrier, but also as a specific antigen to capture anthrax-specific antibodies. As results, purified EA1-MPH forms a single layer of crystalline nanostructure through self-assembly. Our chimeric nanocatalyst greatly improves enzymatic stability of MPH. When applied to the detection of anthrax-specific antibodies in serum samples, the detection of our EA1-MPH nanostructure is nearly 300 times more sensitive than that of the unassembled complex. Together, it is shown that it is possible to build a functional and highly sensitive nanosensor based on S-layer protein. In conclusion, our present study should serve as a model for the development of other multifunctional nanomaterials using S-layer proteins.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-12
摘要: Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the regulation of cortical radial migration. We show that Ezh2 knockdown leads to disturbed neuronal orientation, which results in the impairment of radial migration. Further results reveal that this migration deficiency may be due to the derepression of Reelin transcription in the migrating neurons. Our study provides evidence that epigenetic regulation of Reelin by Ezh2 maintains appropriate Reelin expression pattern to fulfill proper orientation of migrating neurons.
分类: 生物学 >> 生物物理学 >> 生物物理、生物化学与分子生物学 提交时间: 2016-05-12
摘要: Pathogenic mycobacteria transport virulence factors across their complex cell wall via a type VII secretion system (T7SS)/early secreted antigenic target-6 of kDa secretion system (ESX). ESX conserved component (Ecc) B, a core component of the T7SS architecture, is predicted to be a membrane bound protein, but little is known about its structure and function. Here, we characterize EccB1, showing that it is an ATPase with no sequence or structural homology to other ATPases located in the cell envelope of Mycobacterium tuberculosis H37Rv. We obtained the crystal structure of an EccB1-DN72 truncated transmembrane helix and performed modeling and ATP docking studies, showing that EccB1 likely exists as a hexamer. Sequence alignment and ATPase activity determination of EccB1 homologues indicated the presence of 3 conserved motifs in the N- and C-terminals of EccB1-DN72 that assemble together between 2 membrane proximal domains of the EccB1-DN72 monomer. Models of the EccB1 hexamer show that 2 of the conserved motifs are involved in ATPase activity and form an ATP binding pocket located on the surface of 2 adjacent molecules. Our results suggest that EccB may act as the energy provider in the transport of T7SS virulence factors and may be involved in the formation of a channel across the mycomembrane.
分类: 物理学 >> 核物理学 提交时间: 2016-08-30
摘要: The liquid scintillator (LS) has been widely utilized in the past, running and future neutrino experiments, and requirement to the LS radio-purity is higher and higher. The water extraction is a powerful method to remove soluble radioactive nuclei, and a mini-extraction station has been constructed. To evaluate the extraction efficiency and optimize the operation parameters, a setup to load radioactivity to LS and a laboratory scale setup to measure radioactivity which use Bi^{212}-Po^{212}-Pb^{208} cascade decay are developed. Experiences from laboratory study will be useful to large scale water extraction plants design and the optimization of working in future.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-11
摘要: Detection of Bacillus anthracis in the field, whether as a natural infection or as a biothreat remains challenging. Here we have developed a new lateral-flow immunochromatographic assay (LFIA) for B. anthracis spore detection based on the fact that conjugates of B. anthracis spores and super-paramagnetic particles labeled with antibodies will block the pores of chromatographic strips and form retention lines on the strips, instead of the conventionally reported test lines and control lines in classic LFIA. As a result, this new LFIA can simultaneously realize optical, magnetic and naked-eye detection by analyzing signals from the retention lines. As few as 500-700 pure B. anthracis spores can be recognized with CV values less than 8.31% within 5 min of chromatography and a total time of 20 min. For powdery sample tests, this LFIA can endure interference from 25% (w/v) milk, 10% (w/v) baking soda and 10% (w/v) starch without any sample pre-treatment, and has a corresponding detection limit of 6 x 10(4) spores/g milk powder, 2 x 10(5) spores/g starch and 5 x 10(5) spores/g baking soda. Compared with existing methods, this new approach is very competitive in terms of sensitivity, specificity, cost and ease of operation. This proof-of-concept study can also be extended for detection of many other large-sized analytes. (C) 2014 The Authors. Published by Elsevier B.V.
分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: First-principles calculations combined with XRD simulations are performed to systematically study crystal structures, bonding characteristics and electronic structures of LixCoSiO4 (x = 2.0, 1.5, 1.0) polymorphs with symmetries Pmn21-DP and Pbn21. The calculated average voltages by lithium extraction agree well with available experiments. CoO4 tetrahedron is the key structural unit to track the process of delithiation. The oxidation of CoO4 tetrahedron results in a special pattern of bonding characteristic, which corresponds to spin ordering and may be observable in XRD spectra according to simulation. We find delithiated phases are intrinsic Mott insulators, electronic band gaps change from Mott− Hubbard-type to charge-transfer-type during lithium removing. The swapping of near-gap states is associated with the contraction of the oxidized CoO4 units, indicating Peierls distortions that may be the physical origin of capacity degrading of Co−silicate chemistry.
分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: We reported the favorable cathode buffer layer based on a blend of ZnO nanoparticles (NPs) and TiO2 nanorods (NRs) applied to inverted solar cells. In addition to the high optical transmittance, the resultant blend film gave a relatively dense film with lower roughness than that of the respective single-component film. This improved the interface contact between the buffer layer and photoactive layer and therefore reduced the contact resistance and leakage current. Moreover, the combination of NRs and NPs increased the efficiency of electron transport and collection by providing both a direct path for electron transport from TiO2 NRs and a large contact area between ZnO NPs and the active layer. Consequently, both the short-circuit current density (Jsc) and fill factor (FF) in the device were improved, leading to an improvement of the device performance. The best power conversion efficiency (PCE) based on the blend film as the buffer layer reached 8.82%, which was preferable to those of a single ZnO NP film (7.76%) and a TiO2 NR-based device (7.66%). KEYWORDS: ZnO nanoparticles, TiO2 nanorods, blend film, cathode buffer layer, inverted solar cells
分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: In this paper, we reported that ZnO nanoparticles (NPs) film modified with C60 pyrrolidine tris-acid ethyl ester (PyC60) was used as cathode buffer layer in inverted polymer solar cells. The resultant device with a blend of PTB7:PC71BM as photoactive materials exhibited an open-circuit voltage (Voc) of 0.753 V, a short-circuit current (Jsc) of 16.04 mA cm 2, a fill factor (FF) of 72.5%, and an overall power conversion efficiency (PCE) of 8.76%. It was higher than the control devices based on sole ZnO NPs film or ZnO: PyC60 hybrid film as cathode buffer layer. It was found that the morphology improvement of ZnO/PyC60 film contributed to reducing series loss and interfacial charge recombination. In addition, it improved the interfacial contact with photoactive layer. The results increased electron injection and collection efficiency, and improved FF.
分类: 光学 >> 量子光学 提交时间: 2023-02-19
摘要: Establishing and approaching the fundamental limit of orbital angular momentum (OAM) multiplexing are necessary and increasingly urgent for current multiple-input multiple-output research. In this work, we elaborate the fundamental limit in terms of independent scattering channels (or degrees of freedom of scattered fields) through angular-spectral analysis, in conjunction with a rigorous Green function method. The scattering channel limit is universal for arbitrary spatial mode multiplexing, which is launched by a planar electromagnetic device, such as antenna, metasurface, etc, with a predefined physical size. As a proof of concept, we demonstrate both theoretically and experimentally the limit by a metasurface hologram that transforms orthogonal OAM modes to plane-wave modes scattered at critically separated angular-spectral regions. Particularly, a minimax optimization algorithm is applied to suppress angular spectrum aliasing, achieving good performances in both full-wave simulation and experimental measurement at microwave frequencies. This work offers a theoretical upper bound and corresponding approach route for engineering designs of OAM multiplexing.
分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: We used cesium stearate (CsSt) to modify the interface of the electron- extracting contact in inverted organic solar cells. Surface microstructure, optical properties, and electrical characterization as well as exciton generation rate and dissociation probability were investigated to understand the impact of CsSt on the interface contact. The results indicated that by incorporation of CsSt, the surface morphology and energy level as well as conductivity of a zinc oxide (ZnO) film were improved. On the basis of the above properties, highly efficient inverted organic solar cells have been demonstrated by using a ZnO nanoparticle film and CsSt stacked bilayer structure as the cathode interfacial layer. The insertion of a CsSt layer between the ZnO film and active layer improved the electron extraction efficiency, and a high power conversion efficiency (PCE) of 8.69% was achieved. The PCE was improved by 20% as compared to the reference device using a ZnO-only electron extraction layer.
分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: In this study, (001) and (101)-orientated polycrystalline SnO films were respectively fabricated. The preferred orientation conversion was observed by modifying the stoichiometry of the SnO films. It was revealed that the O-rich and Sn-rich SnO films favor (001) and (101) grain orientations, respectively. Moreover, based on the Raman selection rule and our experimental results, the 110 cm 1 Raman peak is assigned to the low- frequency Eg mode of SnO. The Raman intensity ratio between the 110 cm 1 and 210 cm 1 peak of SnO increases with the relative texture coefficient of the (101) grain orientation but decreases with that of the (001) one, demonstrating that the Raman characteristic information could be used as fingerprint recognition to mutually predict the crystallographic texture of SnO films.